TY - JOUR
T1 - Age-related histopathologic changes in the human cochlea
T2 - A temporal bone study
AU - Kusunoki, Takeshi
AU - Cureoglu, Sebahattin
AU - Schachern, Patricia A.
AU - Baba, Kazuyasu
AU - Kariya, Shin
AU - Paparella, Michael M.
N1 - Funding Information:
This work was supported in part by NIH-NIDCD Grant P30 DC04660, by the Lions International of Minnesota, and the International Hearing Foundation.
PY - 2004/12
Y1 - 2004/12
N2 - Previous reports on aging of human cochlea included subjects with ear diseases or ototoxic drugs. We studied spiral ganglion cells, hair cells, and lateral wall of cochlea from subjects without ear disease or ototoxic drugs. This study included 39 temporal bones from 24 subjects aged 1 day to 86 years. We assessed standard cytocochleograms, mean loss of fibrocytes in spiral ligament, and areas of stria vascularis. Losses of outer hair cells and fibrocytes were significantly greater in childern, adults, and the elderly compared with infants. Spiral ganglion cell loss was significantly greater in adults and elderly compared with infants and children. Areas of stria vascularis of infants were significantly larger than the elderly. Degenerative changes of outer hair cells occur in children but spiral ganglion cells remain the same until around 20 years. Degeneration of stria vascularis due to aging appears to be slower than spiral ligament. EBM rating: C.
AB - Previous reports on aging of human cochlea included subjects with ear diseases or ototoxic drugs. We studied spiral ganglion cells, hair cells, and lateral wall of cochlea from subjects without ear disease or ototoxic drugs. This study included 39 temporal bones from 24 subjects aged 1 day to 86 years. We assessed standard cytocochleograms, mean loss of fibrocytes in spiral ligament, and areas of stria vascularis. Losses of outer hair cells and fibrocytes were significantly greater in childern, adults, and the elderly compared with infants. Spiral ganglion cell loss was significantly greater in adults and elderly compared with infants and children. Areas of stria vascularis of infants were significantly larger than the elderly. Degenerative changes of outer hair cells occur in children but spiral ganglion cells remain the same until around 20 years. Degeneration of stria vascularis due to aging appears to be slower than spiral ligament. EBM rating: C.
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U2 - 10.1016/j.otohns.2004.05.022
DO - 10.1016/j.otohns.2004.05.022
M3 - Article
C2 - 15577787
AN - SCOPUS:9644273910
SN - 0194-5998
VL - 131
SP - 897
EP - 903
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 6
ER -