Age-related decline in bone density among ethnically diverse older men

Y. Sheu, J. A. Cauley, V. W. Wheeler, A. L. Patrick, C. H. Bunker, K. E. Ensrud, E. S. Orwoll, J. M. Zmuda

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32 Scopus citations


Summary: We compared rates of BMD decline in older men of diverse ethnic backgroud. The rate of bone loss was statistically equivalent between men of African and Caucasian descent. Introduction: Race differences in peak bone mineral density (BMD) are well established, but the magnitude of bone loss among non-white men has not been well characterized. Our objective was to compare and contrast the rates of decline in BMD with aging among older men of different race/ethnic groups. Methods: The rate of decline in hip BMD was measured by dual-energy X-ray absorptiometry (Hologic QDR-4500 W) with an average follow-up of 4.6 years in 3,869 Caucasian, 138 African American, 145 Asian, and 334 Afro-Caribbean men aged≥65 years (Mean ages: 73±5, 70±4, 72±5, 71±5 years, respectively). Results: The annual rate of decline in BMD at the femoral neck was -0.32%, -0.42%, -0.09%, and -0.44%/year for Caucasian, African American, Asian, and Afro-Caribbean men, respectively (p<0.05 for Caucasian versus Asian). Although men of African ancestry have higher peak BMD than Caucasians, rates of decline in BMD with aging appear to be statistically equivalent in our study. In contrast, Asian men experienced a slower rate of decline in BMD compared with Caucasians and African Americans. Conclusion: More studies are needed to better define the natural history of and factors associated with bone loss among non-white men.

Original languageEnglish (US)
Pages (from-to)599-605
Number of pages7
JournalOsteoporosis International
Issue number2
StatePublished - Feb 2011

Bibliographical note

Funding Information:
The Osteoporotic Fractures in Men (MrOS) Study is supported by National Institutes of Health funding. The following institutes provide support: the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute on Aging (NIA), the National Center for Research Resources (NCRR), and NIH Roadmap for Medical Research under the following grant numbers: U01 AR45580, U01 AR45614, U01 AR45632, U01 AR45647, U01 AR45654, U01 AR45583, U01 AG18197, U01-AG027810, and UL1 RR024140. The Tobago Bone Health Study was supported in part by grant R01-AR049747 from NIAMS and by R01-CA84950 from the National Cancer Institute. Yahtyng Sheu was supported as a post-doctoral fellow on National Institute on Aging grant T32-AG000181-16.


  • BMD
  • Bone loss
  • Men
  • Osteoporosis
  • Race


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