Age-related changes in microarchitecture and mineralization of cancellous bone in the porcine mandibular condyle

Nop M.B.K. Willems; Lars Mulder; Geerling E.J. Langenbach; Thorsten Grünheid; Andrej Zentner; Theo M.G.J. van Eijden

doi:10.1016/j.jsb.2006.12.011

Age-related changes in microarchitecture and mineralization of cancellous bone in the porcine mandibular condyle

Nop M.B.K. Willems, Lars Mulder, Geerling E.J. Langenbach, Thorsten Grünheid, Andrej Zentner, Theo M.G.J. van Eijden

Developmental and Surgical Sciences

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The mandibular condyle is considered a good model for developing cancellous bone because of its rapid growth and high rate of remodeling. The aim of the present study was to analyze the simultaneous changes in microarchitecture and mineralization of cancellous bone during development in a three-dimensional fashion. Eight mandibular condyles of pigs aged 8 weeks prepartum to 108 weeks postpartum were scanned using microCT with an isotropic spatial resolution of 10 μm. The number of trabeculae decreased during development, whereas both the trabecular thickness and the distance between the trabeculae increased. The bone surface to volume ratio decreased during development, possibly limiting the amount of (re)modeling. Both the mean degree of mineralization and intratrabecular differences in mineralization between the surfaces and cores of trabecular elements increased during development. The trabecular surfaces were more highly mineralized in the older condyles compared to the younger ones. Together with the observed decrease in the relative size of trabecular surface, this finding suggests a decrease in (re)modeling activity during development. In accordance with the general growth and development of the pig, it was concluded that most developmental changes in cancellous bone occur until the age of 40 weeks postpartum.

Original language	English (US)
Pages (from-to)	421-427
Number of pages	7
Journal	Journal of Structural Biology
Volume	158
Issue number	3
DOIs	https://doi.org/10.1016/j.jsb.2006.12.011
State	Published - Jun 2007

Bibliographical note

Funding Information:
The authors are grateful to Jan Harm Koolstra for critically reading the manuscript, Irene Aartman for statistical advices, Peter Brugman for analysis, Rijk Gihaux for technical assistance, and Gert van Beek for his conscientious help in the collection of the material for the present study. This study was institutionally supported by the Inter-University Research School of Dentistry, through the Academic Centre for Dentistry Amsterdam (ACTA).

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

Growth
MicroCT
Pig
Remodeling
Trabecular bone

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10.1016/j.jsb.2006.12.011

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title = "Age-related changes in microarchitecture and mineralization of cancellous bone in the porcine mandibular condyle",

abstract = "The mandibular condyle is considered a good model for developing cancellous bone because of its rapid growth and high rate of remodeling. The aim of the present study was to analyze the simultaneous changes in microarchitecture and mineralization of cancellous bone during development in a three-dimensional fashion. Eight mandibular condyles of pigs aged 8 weeks prepartum to 108 weeks postpartum were scanned using microCT with an isotropic spatial resolution of 10 μm. The number of trabeculae decreased during development, whereas both the trabecular thickness and the distance between the trabeculae increased. The bone surface to volume ratio decreased during development, possibly limiting the amount of (re)modeling. Both the mean degree of mineralization and intratrabecular differences in mineralization between the surfaces and cores of trabecular elements increased during development. The trabecular surfaces were more highly mineralized in the older condyles compared to the younger ones. Together with the observed decrease in the relative size of trabecular surface, this finding suggests a decrease in (re)modeling activity during development. In accordance with the general growth and development of the pig, it was concluded that most developmental changes in cancellous bone occur until the age of 40 weeks postpartum.",

keywords = "Growth, MicroCT, Pig, Remodeling, Trabecular bone",

author = "Willems, {Nop M.B.K.} and Lars Mulder and Langenbach, {Geerling E.J.} and Thorsten Gr{\"u}nheid and Andrej Zentner and {van Eijden}, {Theo M.G.J.}",

note = "Funding Information: The authors are grateful to Jan Harm Koolstra for critically reading the manuscript, Irene Aartman for statistical advices, Peter Brugman for analysis, Rijk Gihaux for technical assistance, and Gert van Beek for his conscientious help in the collection of the material for the present study. This study was institutionally supported by the Inter-University Research School of Dentistry, through the Academic Centre for Dentistry Amsterdam (ACTA). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2007",

month = jun,

doi = "10.1016/j.jsb.2006.12.011",

language = "English (US)",

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AU - Willems, Nop M.B.K.

AU - Mulder, Lars

AU - Langenbach, Geerling E.J.

AU - Grünheid, Thorsten

AU - Zentner, Andrej

AU - van Eijden, Theo M.G.J.

N1 - Funding Information: The authors are grateful to Jan Harm Koolstra for critically reading the manuscript, Irene Aartman for statistical advices, Peter Brugman for analysis, Rijk Gihaux for technical assistance, and Gert van Beek for his conscientious help in the collection of the material for the present study. This study was institutionally supported by the Inter-University Research School of Dentistry, through the Academic Centre for Dentistry Amsterdam (ACTA). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2007/6

Y1 - 2007/6

N2 - The mandibular condyle is considered a good model for developing cancellous bone because of its rapid growth and high rate of remodeling. The aim of the present study was to analyze the simultaneous changes in microarchitecture and mineralization of cancellous bone during development in a three-dimensional fashion. Eight mandibular condyles of pigs aged 8 weeks prepartum to 108 weeks postpartum were scanned using microCT with an isotropic spatial resolution of 10 μm. The number of trabeculae decreased during development, whereas both the trabecular thickness and the distance between the trabeculae increased. The bone surface to volume ratio decreased during development, possibly limiting the amount of (re)modeling. Both the mean degree of mineralization and intratrabecular differences in mineralization between the surfaces and cores of trabecular elements increased during development. The trabecular surfaces were more highly mineralized in the older condyles compared to the younger ones. Together with the observed decrease in the relative size of trabecular surface, this finding suggests a decrease in (re)modeling activity during development. In accordance with the general growth and development of the pig, it was concluded that most developmental changes in cancellous bone occur until the age of 40 weeks postpartum.

AB - The mandibular condyle is considered a good model for developing cancellous bone because of its rapid growth and high rate of remodeling. The aim of the present study was to analyze the simultaneous changes in microarchitecture and mineralization of cancellous bone during development in a three-dimensional fashion. Eight mandibular condyles of pigs aged 8 weeks prepartum to 108 weeks postpartum were scanned using microCT with an isotropic spatial resolution of 10 μm. The number of trabeculae decreased during development, whereas both the trabecular thickness and the distance between the trabeculae increased. The bone surface to volume ratio decreased during development, possibly limiting the amount of (re)modeling. Both the mean degree of mineralization and intratrabecular differences in mineralization between the surfaces and cores of trabecular elements increased during development. The trabecular surfaces were more highly mineralized in the older condyles compared to the younger ones. Together with the observed decrease in the relative size of trabecular surface, this finding suggests a decrease in (re)modeling activity during development. In accordance with the general growth and development of the pig, it was concluded that most developmental changes in cancellous bone occur until the age of 40 weeks postpartum.

KW - Growth

KW - MicroCT

KW - Pig

KW - Remodeling

KW - Trabecular bone

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Age-related changes in microarchitecture and mineralization of cancellous bone in the porcine mandibular condyle

Abstract

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Keywords

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