Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues

Keyphrases

• Age-related 100%
• Germ Cells 100%
• Somatic Tissues 100%
• Mitochondrial mutations 100%
• Mammalian Oocyte 100%
• De-novo mutations 80%
• Duplex Sequencing 60%
• Pedigree 40%
• Mitochondrial DNA 40%
• Aged Mice 40%
• Mutation Frequency 40%
• Aging 20%
• Genetic Variation 20%
• Genetic Disease 20%
• Mutagenesis 20%
• Error Rate 20%
• Genetic Variants 20%
• Mutation Rate 20%
• Human Society 20%
• Sequencing Technology 20%
• Highly Accurate 20%
• Order of Magnitude 20%
• Mutation Pattern 20%
• Modern Humans 20%
• Rate 1 20%
• Selection Effect 20%
• Sequence Method 20%
• Mitochondrial DNA mutation 20%
• Mutation Accumulation 20%
• Genetic Drift 20%
• Evolutionary Forces 20%
• Mitochondrial Genetics 20%
• Meiotic Arrest 20%
• Delayed Reproduction 20%
• DNA Turnover 20%
• Pedigree Study 20%
• Mitochondrial DNA Region 20%
• Low-frequency mutation 20%
• Mutagenesis Mechanism 20%

Biochemistry, Genetics and Molecular Biology

• Germ Cell 100%
• Germline 80%
• Mutation Rate 80%
• Mitochondrial DNA 80%
• Pedigree 60%
• Mutagenesis 40%
• Genetic Divergence 40%
• Genetic Disorder 20%
• DNA Mutation 20%
• Mitochondrial Genetics 20%
• Genetic Variation 20%
• Maturation 20%
• Mutation Accumulation 20%
• Genetic Drift 20%