Age of initiation and transition times to tobacco dependence: Early onset and rapid escalated use increase risk for dependence severity

Spencer B. Huggett, Margeret Keyes, William G Iacono, Matt Mc Gue, Robin P. Corley, John K. Hewitt, Michael C. Stallings

Research output: Contribution to journalArticle

Abstract

Background: Research indicates that early tobacco initiation increases risk for dependence, but despite this, early initiation is associated with slower transitions to escalated tobacco use. In contrast to these findings, other studies suggest that rapid escalated tobacco use is associated with increased dependence outcomes. Methods: Our sample was comprised of 5668 twins (2834 twin-pairs, mean age: 26.89, s.d = 4.42, 53.67% female, 57.69% monozygotic) from Colorado and Minnesota twin cohorts. We assessed the associations between 1) age of tobacco initiation and the speed of transitions (latency) to tobacco problem use and dependence and the associations between 2) age of initiation and latencies to tobacco problem use and dependence with tobacco dependence symptom severity. To further understand the etiological unfolding of these processes, we conducted univariate twin models and causally informative co-twin control models. Results: After adjustment for covariates, we found that early tobacco initiation was associated with a slower transition from initiation to problem use but a faster transition from problem use to dependence. Additionally, we found that earlier initiation and faster transitions to tobacco problem use and dependence predicted greater tobacco dependence severity within twin pairs (consistent with causal influences). The contribution of shared genetic and environmental factors was also evident for these relationships. Conclusions: Our study further disentangles the role of early initiation with transition times to tobacco problem use and dependence. In addition to common risk factors, we found potential causal roles for early tobacco initiation and rapid escalated tobacco use with increased risk for tobacco dependence severity.

Original languageEnglish (US)
Pages (from-to)104-110
Number of pages7
JournalDrug and alcohol dependence
Volume202
DOIs
StatePublished - Sep 1 2019

Fingerprint

Tobacco Use Disorder
Tobacco
Tobacco Use
Research

Keywords

  • Age of initiation
  • Co-twin control
  • Onset age
  • Speed of transition
  • Tobacco dependence
  • Twins

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

Cite this

Age of initiation and transition times to tobacco dependence : Early onset and rapid escalated use increase risk for dependence severity. / Huggett, Spencer B.; Keyes, Margeret; Iacono, William G; Mc Gue, Matt; Corley, Robin P.; Hewitt, John K.; Stallings, Michael C.

In: Drug and alcohol dependence, Vol. 202, 01.09.2019, p. 104-110.

Research output: Contribution to journalArticle

Huggett, Spencer B. ; Keyes, Margeret ; Iacono, William G ; Mc Gue, Matt ; Corley, Robin P. ; Hewitt, John K. ; Stallings, Michael C. / Age of initiation and transition times to tobacco dependence : Early onset and rapid escalated use increase risk for dependence severity. In: Drug and alcohol dependence. 2019 ; Vol. 202. pp. 104-110.
@article{5519f72a651e453f81b7d85ecb04a623,
title = "Age of initiation and transition times to tobacco dependence: Early onset and rapid escalated use increase risk for dependence severity",
abstract = "Background: Research indicates that early tobacco initiation increases risk for dependence, but despite this, early initiation is associated with slower transitions to escalated tobacco use. In contrast to these findings, other studies suggest that rapid escalated tobacco use is associated with increased dependence outcomes. Methods: Our sample was comprised of 5668 twins (2834 twin-pairs, mean age: 26.89, s.d = 4.42, 53.67{\%} female, 57.69{\%} monozygotic) from Colorado and Minnesota twin cohorts. We assessed the associations between 1) age of tobacco initiation and the speed of transitions (latency) to tobacco problem use and dependence and the associations between 2) age of initiation and latencies to tobacco problem use and dependence with tobacco dependence symptom severity. To further understand the etiological unfolding of these processes, we conducted univariate twin models and causally informative co-twin control models. Results: After adjustment for covariates, we found that early tobacco initiation was associated with a slower transition from initiation to problem use but a faster transition from problem use to dependence. Additionally, we found that earlier initiation and faster transitions to tobacco problem use and dependence predicted greater tobacco dependence severity within twin pairs (consistent with causal influences). The contribution of shared genetic and environmental factors was also evident for these relationships. Conclusions: Our study further disentangles the role of early initiation with transition times to tobacco problem use and dependence. In addition to common risk factors, we found potential causal roles for early tobacco initiation and rapid escalated tobacco use with increased risk for tobacco dependence severity.",
keywords = "Age of initiation, Co-twin control, Onset age, Speed of transition, Tobacco dependence, Twins",
author = "Huggett, {Spencer B.} and Margeret Keyes and Iacono, {William G} and {Mc Gue}, Matt and Corley, {Robin P.} and Hewitt, {John K.} and Stallings, {Michael C.}",
year = "2019",
month = "9",
day = "1",
doi = "10.1016/j.drugalcdep.2019.04.027",
language = "English (US)",
volume = "202",
pages = "104--110",
journal = "Drug and Alcohol Dependence",
issn = "0376-8716",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Age of initiation and transition times to tobacco dependence

T2 - Early onset and rapid escalated use increase risk for dependence severity

AU - Huggett, Spencer B.

AU - Keyes, Margeret

AU - Iacono, William G

AU - Mc Gue, Matt

AU - Corley, Robin P.

AU - Hewitt, John K.

AU - Stallings, Michael C.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Background: Research indicates that early tobacco initiation increases risk for dependence, but despite this, early initiation is associated with slower transitions to escalated tobacco use. In contrast to these findings, other studies suggest that rapid escalated tobacco use is associated with increased dependence outcomes. Methods: Our sample was comprised of 5668 twins (2834 twin-pairs, mean age: 26.89, s.d = 4.42, 53.67% female, 57.69% monozygotic) from Colorado and Minnesota twin cohorts. We assessed the associations between 1) age of tobacco initiation and the speed of transitions (latency) to tobacco problem use and dependence and the associations between 2) age of initiation and latencies to tobacco problem use and dependence with tobacco dependence symptom severity. To further understand the etiological unfolding of these processes, we conducted univariate twin models and causally informative co-twin control models. Results: After adjustment for covariates, we found that early tobacco initiation was associated with a slower transition from initiation to problem use but a faster transition from problem use to dependence. Additionally, we found that earlier initiation and faster transitions to tobacco problem use and dependence predicted greater tobacco dependence severity within twin pairs (consistent with causal influences). The contribution of shared genetic and environmental factors was also evident for these relationships. Conclusions: Our study further disentangles the role of early initiation with transition times to tobacco problem use and dependence. In addition to common risk factors, we found potential causal roles for early tobacco initiation and rapid escalated tobacco use with increased risk for tobacco dependence severity.

AB - Background: Research indicates that early tobacco initiation increases risk for dependence, but despite this, early initiation is associated with slower transitions to escalated tobacco use. In contrast to these findings, other studies suggest that rapid escalated tobacco use is associated with increased dependence outcomes. Methods: Our sample was comprised of 5668 twins (2834 twin-pairs, mean age: 26.89, s.d = 4.42, 53.67% female, 57.69% monozygotic) from Colorado and Minnesota twin cohorts. We assessed the associations between 1) age of tobacco initiation and the speed of transitions (latency) to tobacco problem use and dependence and the associations between 2) age of initiation and latencies to tobacco problem use and dependence with tobacco dependence symptom severity. To further understand the etiological unfolding of these processes, we conducted univariate twin models and causally informative co-twin control models. Results: After adjustment for covariates, we found that early tobacco initiation was associated with a slower transition from initiation to problem use but a faster transition from problem use to dependence. Additionally, we found that earlier initiation and faster transitions to tobacco problem use and dependence predicted greater tobacco dependence severity within twin pairs (consistent with causal influences). The contribution of shared genetic and environmental factors was also evident for these relationships. Conclusions: Our study further disentangles the role of early initiation with transition times to tobacco problem use and dependence. In addition to common risk factors, we found potential causal roles for early tobacco initiation and rapid escalated tobacco use with increased risk for tobacco dependence severity.

KW - Age of initiation

KW - Co-twin control

KW - Onset age

KW - Speed of transition

KW - Tobacco dependence

KW - Twins

UR - http://www.scopus.com/inward/record.url?scp=85069580531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069580531&partnerID=8YFLogxK

U2 - 10.1016/j.drugalcdep.2019.04.027

DO - 10.1016/j.drugalcdep.2019.04.027

M3 - Article

C2 - 31330330

AN - SCOPUS:85069580531

VL - 202

SP - 104

EP - 110

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

SN - 0376-8716

ER -