Age-dependent effects of treadmill exercise during a period of inactivity

P. Arora; A. D. Husom; D. A. Ferrington; L. V. Thompson

doi:10.1016/j.exger.2008.03.006

Age-dependent effects of treadmill exercise during a period of inactivity

P. Arora, A. D. Husom, D. A. Ferrington, L. V. Thompson

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Abstract

The objective of this study was to investigate the effect of a treadmill exercise protocol to prevent muscle weakness, atrophy and alterations in calcium regulation in adult, old and very old rats. Adult (7-12 months), old (29-30 months) and very old (34-36 months) F344BNF₁ rats were randomly assigned to weight bearing (WB), weight bearing exercise (WBX), non-weight bearing (NWB) and non-weight bearing exercise (NWBX) groups. The WB group was considered the sedentary-control animals. NWB rats were hindlimb unweighted for 14 days. WBX and NWBX groups were exercised on a treadmill for approximately 15 min four times daily. The contractile properties [diameter, peak active force (P₀), specific tension (P₀/CSA)] of single myosin heavy chain type II fibers and Ca regulation [Ca²⁺ dependent ATPase activity] were determined. Fiber diameter reduced by 24% in the very old rats with NWB. P₀ and P₀/CSA declined in the young adult and very old rats with NWB. NWBX attenuated these changes in the young and very old rats. Ca²⁺ dependent ATPase activity increased with treadmill exercise during non-weight bearing in the young animals. In conclusion, the treadmill exercise is beneficial in attenuating the non-weight bearing-induced changes in the individual MHC type II muscle fibers of the gastrocnemius muscle.

Original language	English (US)
Pages (from-to)	668-673
Number of pages	6
Journal	Experimental Gerontology
Volume	43
Issue number	7
DOIs	https://doi.org/10.1016/j.exger.2008.03.006
State	Published - Jul 2008

Keywords

Aging
Calcium regulation
F344BNF1 rats
Gastrocnemius muscle
Hindlimb unweighting
MHC type II fibers
Muscle atrophy
Muscle weakness
Single fiber contractile properties
Treadmill exercise

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title = "Age-dependent effects of treadmill exercise during a period of inactivity",

abstract = "The objective of this study was to investigate the effect of a treadmill exercise protocol to prevent muscle weakness, atrophy and alterations in calcium regulation in adult, old and very old rats. Adult (7-12 months), old (29-30 months) and very old (34-36 months) F344BNF1 rats were randomly assigned to weight bearing (WB), weight bearing exercise (WBX), non-weight bearing (NWB) and non-weight bearing exercise (NWBX) groups. The WB group was considered the sedentary-control animals. NWB rats were hindlimb unweighted for 14 days. WBX and NWBX groups were exercised on a treadmill for approximately 15 min four times daily. The contractile properties [diameter, peak active force (P0), specific tension (P0/CSA)] of single myosin heavy chain type II fibers and Ca regulation [Ca2+ dependent ATPase activity] were determined. Fiber diameter reduced by 24% in the very old rats with NWB. P0 and P0/CSA declined in the young adult and very old rats with NWB. NWBX attenuated these changes in the young and very old rats. Ca2+ dependent ATPase activity increased with treadmill exercise during non-weight bearing in the young animals. In conclusion, the treadmill exercise is beneficial in attenuating the non-weight bearing-induced changes in the individual MHC type II muscle fibers of the gastrocnemius muscle.",

keywords = "Aging, Calcium regulation, F344BNF1 rats, Gastrocnemius muscle, Hindlimb unweighting, MHC type II fibers, Muscle atrophy, Muscle weakness, Single fiber contractile properties, Treadmill exercise",

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AU - Arora, P.

AU - Husom, A. D.

AU - Ferrington, D. A.

AU - Thompson, L. V.

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N2 - The objective of this study was to investigate the effect of a treadmill exercise protocol to prevent muscle weakness, atrophy and alterations in calcium regulation in adult, old and very old rats. Adult (7-12 months), old (29-30 months) and very old (34-36 months) F344BNF1 rats were randomly assigned to weight bearing (WB), weight bearing exercise (WBX), non-weight bearing (NWB) and non-weight bearing exercise (NWBX) groups. The WB group was considered the sedentary-control animals. NWB rats were hindlimb unweighted for 14 days. WBX and NWBX groups were exercised on a treadmill for approximately 15 min four times daily. The contractile properties [diameter, peak active force (P0), specific tension (P0/CSA)] of single myosin heavy chain type II fibers and Ca regulation [Ca2+ dependent ATPase activity] were determined. Fiber diameter reduced by 24% in the very old rats with NWB. P0 and P0/CSA declined in the young adult and very old rats with NWB. NWBX attenuated these changes in the young and very old rats. Ca2+ dependent ATPase activity increased with treadmill exercise during non-weight bearing in the young animals. In conclusion, the treadmill exercise is beneficial in attenuating the non-weight bearing-induced changes in the individual MHC type II muscle fibers of the gastrocnemius muscle.

AB - The objective of this study was to investigate the effect of a treadmill exercise protocol to prevent muscle weakness, atrophy and alterations in calcium regulation in adult, old and very old rats. Adult (7-12 months), old (29-30 months) and very old (34-36 months) F344BNF1 rats were randomly assigned to weight bearing (WB), weight bearing exercise (WBX), non-weight bearing (NWB) and non-weight bearing exercise (NWBX) groups. The WB group was considered the sedentary-control animals. NWB rats were hindlimb unweighted for 14 days. WBX and NWBX groups were exercised on a treadmill for approximately 15 min four times daily. The contractile properties [diameter, peak active force (P0), specific tension (P0/CSA)] of single myosin heavy chain type II fibers and Ca regulation [Ca2+ dependent ATPase activity] were determined. Fiber diameter reduced by 24% in the very old rats with NWB. P0 and P0/CSA declined in the young adult and very old rats with NWB. NWBX attenuated these changes in the young and very old rats. Ca2+ dependent ATPase activity increased with treadmill exercise during non-weight bearing in the young animals. In conclusion, the treadmill exercise is beneficial in attenuating the non-weight bearing-induced changes in the individual MHC type II muscle fibers of the gastrocnemius muscle.

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KW - Calcium regulation

KW - F344BNF1 rats

KW - Gastrocnemius muscle

KW - Hindlimb unweighting

KW - MHC type II fibers

KW - Muscle atrophy

KW - Muscle weakness

KW - Single fiber contractile properties

KW - Treadmill exercise

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JO - Experimental Gerontology

JF - Experimental Gerontology

IS - 7

ER -

Age-dependent effects of treadmill exercise during a period of inactivity

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