Abstract
The objective of this study was to investigate the effect of a treadmill exercise protocol to prevent muscle weakness, atrophy and alterations in calcium regulation in adult, old and very old rats. Adult (7-12 months), old (29-30 months) and very old (34-36 months) F344BNF1 rats were randomly assigned to weight bearing (WB), weight bearing exercise (WBX), non-weight bearing (NWB) and non-weight bearing exercise (NWBX) groups. The WB group was considered the sedentary-control animals. NWB rats were hindlimb unweighted for 14 days. WBX and NWBX groups were exercised on a treadmill for approximately 15 min four times daily. The contractile properties [diameter, peak active force (P0), specific tension (P0/CSA)] of single myosin heavy chain type II fibers and Ca regulation [Ca2+ dependent ATPase activity] were determined. Fiber diameter reduced by 24% in the very old rats with NWB. P0 and P0/CSA declined in the young adult and very old rats with NWB. NWBX attenuated these changes in the young and very old rats. Ca2+ dependent ATPase activity increased with treadmill exercise during non-weight bearing in the young animals. In conclusion, the treadmill exercise is beneficial in attenuating the non-weight bearing-induced changes in the individual MHC type II muscle fibers of the gastrocnemius muscle.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 668-673 |
| Number of pages | 6 |
| Journal | Experimental Gerontology |
| Volume | 43 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2008 |
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Keywords
- Aging
- Calcium regulation
- F344BNF1 rats
- Gastrocnemius muscle
- Hindlimb unweighting
- MHC type II fibers
- Muscle atrophy
- Muscle weakness
- Single fiber contractile properties
- Treadmill exercise
Cite this
Age-dependent effects of treadmill exercise during a period of inactivity. / Arora, P.; Husom, A. D.; Ferrington, D. A.; Thompson, L. V.
In: Experimental Gerontology, Vol. 43, No. 7, 01.07.2008, p. 668-673.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age-dependent effects of treadmill exercise during a period of inactivity
AU - Arora, P.
AU - Husom, A. D.
AU - Ferrington, D. A.
AU - Thompson, L. V.
PY - 2008/7/1
Y1 - 2008/7/1
N2 - The objective of this study was to investigate the effect of a treadmill exercise protocol to prevent muscle weakness, atrophy and alterations in calcium regulation in adult, old and very old rats. Adult (7-12 months), old (29-30 months) and very old (34-36 months) F344BNF1 rats were randomly assigned to weight bearing (WB), weight bearing exercise (WBX), non-weight bearing (NWB) and non-weight bearing exercise (NWBX) groups. The WB group was considered the sedentary-control animals. NWB rats were hindlimb unweighted for 14 days. WBX and NWBX groups were exercised on a treadmill for approximately 15 min four times daily. The contractile properties [diameter, peak active force (P0), specific tension (P0/CSA)] of single myosin heavy chain type II fibers and Ca regulation [Ca2+ dependent ATPase activity] were determined. Fiber diameter reduced by 24% in the very old rats with NWB. P0 and P0/CSA declined in the young adult and very old rats with NWB. NWBX attenuated these changes in the young and very old rats. Ca2+ dependent ATPase activity increased with treadmill exercise during non-weight bearing in the young animals. In conclusion, the treadmill exercise is beneficial in attenuating the non-weight bearing-induced changes in the individual MHC type II muscle fibers of the gastrocnemius muscle.
AB - The objective of this study was to investigate the effect of a treadmill exercise protocol to prevent muscle weakness, atrophy and alterations in calcium regulation in adult, old and very old rats. Adult (7-12 months), old (29-30 months) and very old (34-36 months) F344BNF1 rats were randomly assigned to weight bearing (WB), weight bearing exercise (WBX), non-weight bearing (NWB) and non-weight bearing exercise (NWBX) groups. The WB group was considered the sedentary-control animals. NWB rats were hindlimb unweighted for 14 days. WBX and NWBX groups were exercised on a treadmill for approximately 15 min four times daily. The contractile properties [diameter, peak active force (P0), specific tension (P0/CSA)] of single myosin heavy chain type II fibers and Ca regulation [Ca2+ dependent ATPase activity] were determined. Fiber diameter reduced by 24% in the very old rats with NWB. P0 and P0/CSA declined in the young adult and very old rats with NWB. NWBX attenuated these changes in the young and very old rats. Ca2+ dependent ATPase activity increased with treadmill exercise during non-weight bearing in the young animals. In conclusion, the treadmill exercise is beneficial in attenuating the non-weight bearing-induced changes in the individual MHC type II muscle fibers of the gastrocnemius muscle.
KW - Aging
KW - Calcium regulation
KW - F344BNF1 rats
KW - Gastrocnemius muscle
KW - Hindlimb unweighting
KW - MHC type II fibers
KW - Muscle atrophy
KW - Muscle weakness
KW - Single fiber contractile properties
KW - Treadmill exercise
UR - http://www.scopus.com/inward/record.url?scp=46749157461&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46749157461&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2008.03.006
DO - 10.1016/j.exger.2008.03.006
M3 - Article
C2 - 18445515
AN - SCOPUS:46749157461
VL - 43
SP - 668
EP - 673
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
IS - 7
ER -