Age associations with neural processing of reward anticipation in adolescents with bipolar disorders

Snežana Urošević; Monica M Luciana; Jonathan B Jensen; Eric A. Youngstrom; Kathleen M Thomas

doi:10.1016/j.nicl.2016.03.013

Age associations with neural processing of reward anticipation in adolescents with bipolar disorders

Snežana Urošević, Monica M Luciana, Jonathan B Jensen, Eric A. Youngstrom, Kathleen M Thomas

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Reward/behavioral approach system hypersensitivity is implicated in bipolar disorders (BD) and in normative development during adolescence. Pediatric onset of BD is associated with a more severe illness course. However, little is known about neural processing of rewards in adolescents with BD or developmental (i.e., age) associations with activation of these neural systems. The present study aims to address this knowledge gap. The present sample included 21 adolescents with BD and 26 healthy adolescents, ages 13 to 19. Participants completed a functional magnetic resonance imaging (fMRI) protocol using the Monetary Incentive Delay (MID) task. Behavioral performance was similar between groups. Group differences in BOLD activation during target anticipation and feedback anticipation periods of the task were examined using whole-brain analyses, as were group differences in age effects. During both target anticipation and feedback anticipation, adolescents with BD, compared to adolescents without psychopathology, exhibited decreased engagement of frontal regions involved in cognitive control (i.e., dorsolateral prefrontal cortex). Healthy adolescents exhibited age-related decreases, while adolescents with BD exhibited age-related increases, in activity of other cognitive control frontal areas (i.e., right inferior frontal gyrus), suggesting altered development in the BD group. Longitudinal research is needed to examine potentially abnormal development of cognitive control during reward pursuit in adolescent BD and whether early therapeutic interventions can prevent these potential deviations from normative development.

Original language	English (US)
Pages (from-to)	476-485
Number of pages	10
Journal	NeuroImage: Clinical
Volume	11
DOIs	https://doi.org/10.1016/j.nicl.2016.03.013
State	Published - 2016

Bibliographical note

Funding Information:
The project and Snežana Urošević, Ph.D.'s work on the manuscript were supported by National Institute of Mental Health Grant K01 MH 093621 . This work was also supported by BTRC grants awarded to the Center for Magnetic Resonance Research ( P41 RR008079 , P41 EB015894 , and 1P30 NS076408 ), as well as by the University of Minnesota's Supercomputing Institute and Center for Neurobehavioral Development . The funding agencies had no involvement in study design, data collection and analyses, or in manuscript preparation and submission. Finally, the authors would like to thank Ruskin H. Hunt, Ph.D., for his consultation during data processing and analysis; Tate Halverson, Amanda Yeager, Lily Pfutzenreuter, and all the research staff that contributed to data collection; and especially the research participants and their families.

Publisher Copyright:
© 2016 The Authors. Published by Elsevier Inc.

Keywords

Adolescence
BAS dysregulation
Bipolar disorder
Reward
fMRI

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10.1016/j.nicl.2016.03.013

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title = "Age associations with neural processing of reward anticipation in adolescents with bipolar disorders",

abstract = "Reward/behavioral approach system hypersensitivity is implicated in bipolar disorders (BD) and in normative development during adolescence. Pediatric onset of BD is associated with a more severe illness course. However, little is known about neural processing of rewards in adolescents with BD or developmental (i.e., age) associations with activation of these neural systems. The present study aims to address this knowledge gap. The present sample included 21 adolescents with BD and 26 healthy adolescents, ages 13 to 19. Participants completed a functional magnetic resonance imaging (fMRI) protocol using the Monetary Incentive Delay (MID) task. Behavioral performance was similar between groups. Group differences in BOLD activation during target anticipation and feedback anticipation periods of the task were examined using whole-brain analyses, as were group differences in age effects. During both target anticipation and feedback anticipation, adolescents with BD, compared to adolescents without psychopathology, exhibited decreased engagement of frontal regions involved in cognitive control (i.e., dorsolateral prefrontal cortex). Healthy adolescents exhibited age-related decreases, while adolescents with BD exhibited age-related increases, in activity of other cognitive control frontal areas (i.e., right inferior frontal gyrus), suggesting altered development in the BD group. Longitudinal research is needed to examine potentially abnormal development of cognitive control during reward pursuit in adolescent BD and whether early therapeutic interventions can prevent these potential deviations from normative development.",

keywords = "Adolescence, BAS dysregulation, Bipolar disorder, Reward, fMRI",

author = "Sne{\v z}ana Uro{\v s}evi{\'c} and Luciana, {Monica M} and Jensen, {Jonathan B} and Youngstrom, {Eric A.} and Thomas, {Kathleen M}",

note = "Funding Information: The project and Sne{\v z}ana Uro{\v s}evi{\'c}, Ph.D.'s work on the manuscript were supported by National Institute of Mental Health Grant K01 MH 093621 . This work was also supported by BTRC grants awarded to the Center for Magnetic Resonance Research ( P41 RR008079 , P41 EB015894 , and 1P30 NS076408 ), as well as by the University of Minnesota's Supercomputing Institute and Center for Neurobehavioral Development . The funding agencies had no involvement in study design, data collection and analyses, or in manuscript preparation and submission. Finally, the authors would like to thank Ruskin H. Hunt, Ph.D., for his consultation during data processing and analysis; Tate Halverson, Amanda Yeager, Lily Pfutzenreuter, and all the research staff that contributed to data collection; and especially the research participants and their families. Publisher Copyright: {\textcopyright} 2016 The Authors. Published by Elsevier Inc.",

year = "2016",

doi = "10.1016/j.nicl.2016.03.013",

language = "English (US)",

volume = "11",

pages = "476--485",

journal = "NeuroImage: Clinical",

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T1 - Age associations with neural processing of reward anticipation in adolescents with bipolar disorders

AU - Urošević, Snežana

AU - Luciana, Monica M

AU - Jensen, Jonathan B

AU - Youngstrom, Eric A.

AU - Thomas, Kathleen M

N1 - Funding Information: The project and Snežana Urošević, Ph.D.'s work on the manuscript were supported by National Institute of Mental Health Grant K01 MH 093621 . This work was also supported by BTRC grants awarded to the Center for Magnetic Resonance Research ( P41 RR008079 , P41 EB015894 , and 1P30 NS076408 ), as well as by the University of Minnesota's Supercomputing Institute and Center for Neurobehavioral Development . The funding agencies had no involvement in study design, data collection and analyses, or in manuscript preparation and submission. Finally, the authors would like to thank Ruskin H. Hunt, Ph.D., for his consultation during data processing and analysis; Tate Halverson, Amanda Yeager, Lily Pfutzenreuter, and all the research staff that contributed to data collection; and especially the research participants and their families. Publisher Copyright: © 2016 The Authors. Published by Elsevier Inc.

PY - 2016

Y1 - 2016

N2 - Reward/behavioral approach system hypersensitivity is implicated in bipolar disorders (BD) and in normative development during adolescence. Pediatric onset of BD is associated with a more severe illness course. However, little is known about neural processing of rewards in adolescents with BD or developmental (i.e., age) associations with activation of these neural systems. The present study aims to address this knowledge gap. The present sample included 21 adolescents with BD and 26 healthy adolescents, ages 13 to 19. Participants completed a functional magnetic resonance imaging (fMRI) protocol using the Monetary Incentive Delay (MID) task. Behavioral performance was similar between groups. Group differences in BOLD activation during target anticipation and feedback anticipation periods of the task were examined using whole-brain analyses, as were group differences in age effects. During both target anticipation and feedback anticipation, adolescents with BD, compared to adolescents without psychopathology, exhibited decreased engagement of frontal regions involved in cognitive control (i.e., dorsolateral prefrontal cortex). Healthy adolescents exhibited age-related decreases, while adolescents with BD exhibited age-related increases, in activity of other cognitive control frontal areas (i.e., right inferior frontal gyrus), suggesting altered development in the BD group. Longitudinal research is needed to examine potentially abnormal development of cognitive control during reward pursuit in adolescent BD and whether early therapeutic interventions can prevent these potential deviations from normative development.

AB - Reward/behavioral approach system hypersensitivity is implicated in bipolar disorders (BD) and in normative development during adolescence. Pediatric onset of BD is associated with a more severe illness course. However, little is known about neural processing of rewards in adolescents with BD or developmental (i.e., age) associations with activation of these neural systems. The present study aims to address this knowledge gap. The present sample included 21 adolescents with BD and 26 healthy adolescents, ages 13 to 19. Participants completed a functional magnetic resonance imaging (fMRI) protocol using the Monetary Incentive Delay (MID) task. Behavioral performance was similar between groups. Group differences in BOLD activation during target anticipation and feedback anticipation periods of the task were examined using whole-brain analyses, as were group differences in age effects. During both target anticipation and feedback anticipation, adolescents with BD, compared to adolescents without psychopathology, exhibited decreased engagement of frontal regions involved in cognitive control (i.e., dorsolateral prefrontal cortex). Healthy adolescents exhibited age-related decreases, while adolescents with BD exhibited age-related increases, in activity of other cognitive control frontal areas (i.e., right inferior frontal gyrus), suggesting altered development in the BD group. Longitudinal research is needed to examine potentially abnormal development of cognitive control during reward pursuit in adolescent BD and whether early therapeutic interventions can prevent these potential deviations from normative development.

KW - Adolescence

KW - BAS dysregulation

KW - Bipolar disorder

KW - Reward

KW - fMRI

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JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

ER -

Age associations with neural processing of reward anticipation in adolescents with bipolar disorders

Abstract

Bibliographical note

Keywords

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