Age alone is not a contraindication to kidney donation: Outcomes of donor nephrectomy in the elderly

Oscar K. Serrano, Kunal Yadav, Ananta Bangdiwala, David M. Vock, Ty B. Dunn, Erik B. Finger, Timothy L. Pruett, Arthur J. Matas, Raja Kandaswamy

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14 Scopus citations


With increasing organ demand, living kidney donation from older donors (>60-years-old) has become more common. Between 1975 and 2014, 3752 donor nephrectomies (DN) were performed at University of Minnesota; 167 (4.5%) were >60-years-old Short- and long-term outcomes were compared between contemporaneous >60-years-old and <60-years-old donors. On univariate analysis, >60-years-old were more likely to have had prior abdominal surgery and hypertension; and less likely to smoke. Baseline estimated glomerular filtration rate (eGFR) was lower in >60-years-old (80 ± 16 vs 101 ± 26 mL/min/1.73 m2; P <.001). Intraoperative and postoperative complications were similar, except a higher prevalence of <30 day ileus (3% vs 7%; P =.021) and longer postoperative length of stay (LOS) (4.2 vs 4.6 days; P =.005). On multivariate analysis, <30 day ileus and LOS continued to be significantly greater for >60-years-old After >20 years post-DN, systolic blood pressure was significantly higher among >60-years-old (142 vs 125 mm Hg; P <.001) and HTN was diagnosed earlier (9 vs 14 years). After donation, eGFR was significantly lower for >60-years-old but slope of eGFR and rates of end-stage renal disease (ESRD) were not significantly different >20 years post-DN. Thus, kidney donation among carefully selected >60-years-old poses minimal perioperative risks and no added risk of long-term ESRD.

Original languageEnglish (US)
Article numbere13287
JournalClinical Transplantation
Issue number8
StatePublished - Aug 2018

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© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd


  • donor nephrectomy
  • elderly
  • living donor kidney transplant


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