TY - JOUR
T1 - African ancestry gradient is associated with lower systemic f
2
-isoprostane levels
AU - Annor, Francis
AU - Goodman, Michael
AU - Thyagarajan, Bharat
AU - Okosun, Ike
AU - Doumatey, Ayo
AU - Gower, Barbara A.
AU - Il'yasova, Dora
N1 - Publisher Copyright:
© 2017 Francis Annor et al.
PY - 2017
Y1 - 2017
N2 - Context. Low levels of systemic F2-isoprostanes (F2-IsoP) increase the risk of diabetes and weight gain and were found in African Americans. Low F2-IsoPs could reflect an unfavorable metabolic characteristic, namely, slow mitochondrial metabolism in individuals with African ancestry. Objective. To examine differences in plasma F2-IsoPs in three groups with a priori different proportion of African ancestry: non-Hispanic Whites (NHWs), US-born African Americans (AAs), and West African immigrants (WAI). Design. Cross-sectional study. Setting. Georgia residents recruited from church communities. Participants. 218 males and females 25-74 years of age, who are self-identified as NHW (n=83), AA (n=56), or WAI (n=79). Main Outcome Measure(s). Plasma F2-IsoPs quantified by gas chromatography-mass spectrometry. Results. After adjustment for age, gender, obesity, and other comorbidities, WAI had lower levels of plasma F2-IsoP than AA (beta-coefficient = -9.8, p<0.001) and AA had lower levels than NHW (beta-coefficient = -30.3, p<0.001). Similarly, among healthy nonobese participants, F2-IsoP levels were lowest among WAI, followed by AA, and the highest levels were among NHW. Conclusion. Plasma F2-IsoPs are inversely associated with African ancestry gradient. Additional studies are required to test whether optimization of systemic F2-IsoP levels can serve as means to improve race-specific lifestyle and pharmacological intervention targeted to obesity prevention and treatment.
AB - Context. Low levels of systemic F2-isoprostanes (F2-IsoP) increase the risk of diabetes and weight gain and were found in African Americans. Low F2-IsoPs could reflect an unfavorable metabolic characteristic, namely, slow mitochondrial metabolism in individuals with African ancestry. Objective. To examine differences in plasma F2-IsoPs in three groups with a priori different proportion of African ancestry: non-Hispanic Whites (NHWs), US-born African Americans (AAs), and West African immigrants (WAI). Design. Cross-sectional study. Setting. Georgia residents recruited from church communities. Participants. 218 males and females 25-74 years of age, who are self-identified as NHW (n=83), AA (n=56), or WAI (n=79). Main Outcome Measure(s). Plasma F2-IsoPs quantified by gas chromatography-mass spectrometry. Results. After adjustment for age, gender, obesity, and other comorbidities, WAI had lower levels of plasma F2-IsoP than AA (beta-coefficient = -9.8, p<0.001) and AA had lower levels than NHW (beta-coefficient = -30.3, p<0.001). Similarly, among healthy nonobese participants, F2-IsoP levels were lowest among WAI, followed by AA, and the highest levels were among NHW. Conclusion. Plasma F2-IsoPs are inversely associated with African ancestry gradient. Additional studies are required to test whether optimization of systemic F2-IsoP levels can serve as means to improve race-specific lifestyle and pharmacological intervention targeted to obesity prevention and treatment.
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U2 - 10.1155/2017/8319176
DO - 10.1155/2017/8319176
M3 - Article
C2 - 28250893
AN - SCOPUS:85013455411
SN - 1942-0900
VL - 2017
JO - Oxidative medicine and cellular longevity
JF - Oxidative medicine and cellular longevity
M1 - 8319176
ER -