Affecting Cognition and Quality of Life via Aerobic Exercise in Alzheimer's Disease

Fang Yu, Nathaniel W. Nelson, Kay Savik, Jean F Wyman, Maurice W Dysken, Ulf G Bronas

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Aerobic exercise is a promising behavioral therapy for Alzheimer's disease (AD), yet few studies have investigated the effect of aerobic exercise on cognition in AD. The purpose of this pilot study was to examine the effect of 6-month aerobic exercise on the change in executive function, global cognition, quality of life (QOL), and depression in community-dwelling older adults with mild to moderate AD. A single group, repeated measures design with outcomes measured at baseline, 3 months, and 6 months was used. Results show that there were no significant changes in any measures except for depression (p = .026). There was a trend toward improvement in executive function and QOL with moderate effect sizes (ESs) and a trend toward deterioration in global cognition with moderate to large ESs. Randomized controlled trials are needed to evaluate the therapeutic effect of aerobic exercise in older adults with AD.

Original languageEnglish (US)
Pages (from-to)24-38
Number of pages15
JournalWestern journal of nursing research
Volume35
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • aging
  • cognition
  • dementia
  • exercise
  • quality of life

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