Aerosol transmission of chronic wasting disease in white-tailed deer

Nathaniel D. Denkers, Jeanette Hayes-Klug, Kelly R. Anderson, Davis M. Seelig, Nicholas J. Haley, Sallie J. Dahmes, David A. Osborn, Karl V. Miller, R. J. Warren, Candace K. Mathiason, Edward A. Hoover

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

While the facile transmission of chronic wasting disease (CWD) remains incompletely elucidated, studies in rodents suggest that exposure of the respiratory mucosa may be an efficient pathway. The present study was designed to address this question in the native cervid host. Here, we demonstrate aerosol transmission of CWD to deer with a prion dose>20-fold lower than that used in previous oral inoculations. Inhalation of prions may facilitate transmission of CWD and, perhaps, other prion infections.

Original languageEnglish (US)
Pages (from-to)1890-1892
Number of pages3
JournalJournal of virology
Volume87
Issue number3
DOIs
StatePublished - Feb 1 2013

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Chronic Wasting Disease
chronic wasting disease
Deer
Prions
prions
Odocoileus virginianus
aerosols
Aerosols
respiratory mucosa
Respiratory Mucosa
deer
Inhalation
oral administration
breathing
Rodentia
rodents
dosage
Infection
infection

Cite this

Denkers, N. D., Hayes-Klug, J., Anderson, K. R., Seelig, D. M., Haley, N. J., Dahmes, S. J., ... Hoover, E. A. (2013). Aerosol transmission of chronic wasting disease in white-tailed deer. Journal of virology, 87(3), 1890-1892. https://doi.org/10.1128/JVI.02852-12

Aerosol transmission of chronic wasting disease in white-tailed deer. / Denkers, Nathaniel D.; Hayes-Klug, Jeanette; Anderson, Kelly R.; Seelig, Davis M.; Haley, Nicholas J.; Dahmes, Sallie J.; Osborn, David A.; Miller, Karl V.; Warren, R. J.; Mathiason, Candace K.; Hoover, Edward A.

In: Journal of virology, Vol. 87, No. 3, 01.02.2013, p. 1890-1892.

Research output: Contribution to journalArticle

Denkers, ND, Hayes-Klug, J, Anderson, KR, Seelig, DM, Haley, NJ, Dahmes, SJ, Osborn, DA, Miller, KV, Warren, RJ, Mathiason, CK & Hoover, EA 2013, 'Aerosol transmission of chronic wasting disease in white-tailed deer', Journal of virology, vol. 87, no. 3, pp. 1890-1892. https://doi.org/10.1128/JVI.02852-12
Denkers ND, Hayes-Klug J, Anderson KR, Seelig DM, Haley NJ, Dahmes SJ et al. Aerosol transmission of chronic wasting disease in white-tailed deer. Journal of virology. 2013 Feb 1;87(3):1890-1892. https://doi.org/10.1128/JVI.02852-12
Denkers, Nathaniel D. ; Hayes-Klug, Jeanette ; Anderson, Kelly R. ; Seelig, Davis M. ; Haley, Nicholas J. ; Dahmes, Sallie J. ; Osborn, David A. ; Miller, Karl V. ; Warren, R. J. ; Mathiason, Candace K. ; Hoover, Edward A. / Aerosol transmission of chronic wasting disease in white-tailed deer. In: Journal of virology. 2013 ; Vol. 87, No. 3. pp. 1890-1892.
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