Aerosol transmission of chronic wasting disease in white-tailed deer

Nathaniel D. Denkers, Jeanette Hayes-Klug, Kelly R. Anderson, Davis M. Seelig, Nicholas J. Haley, Sallie J. Dahmes, David A. Osborn, Karl V. Miller, R. J. Warren, Candace K. Mathiason, Edward A. Hoover

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

While the facile transmission of chronic wasting disease (CWD) remains incompletely elucidated, studies in rodents suggest that exposure of the respiratory mucosa may be an efficient pathway. The present study was designed to address this question in the native cervid host. Here, we demonstrate aerosol transmission of CWD to deer with a prion dose>20-fold lower than that used in previous oral inoculations. Inhalation of prions may facilitate transmission of CWD and, perhaps, other prion infections.

Original languageEnglish (US)
Pages (from-to)1890-1892
Number of pages3
JournalJournal of virology
Volume87
Issue number3
DOIs
StatePublished - Feb 2013

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