Adverse Effects of Autoclaved Diets on the Progression of Chronic Kidney Disease and Chronic Kidney Disease-Mineral Bone Disorder in Rats

Annabel Biruete; Shruthi Srinivasan; Kalisha D O'Neill; Colby J Vorland; Kathleen M Hill Gallant; Weijing Cai; Jaime Uribarri; Nancy Johnston; Matthew R Allen; Neal X Chen; Sharon M Moe

doi:10.1159/000506729

Adverse Effects of Autoclaved Diets on the Progression of Chronic Kidney Disease and Chronic Kidney Disease-Mineral Bone Disorder in Rats

Annabel Biruete, Shruthi Srinivasan, Kalisha D O'Neill, Colby J Vorland, Kathleen M Hill Gallant, Weijing Cai, Jaime Uribarri, Nancy Johnston, Matthew R Allen, Neal X Chen, Sharon M Moe

Food Science and Nutrition

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

BACKGROUND: Autoclaving rodent diets is common in laboratory animals, but autoclaving increases the formation of dietary advanced glycation end-products (AGE). We studied the effect of autoclaved (AC) diet alone or in combination with a diet high in bioavailable phosphorus on biochemistries of chronic kidney disease-mineral and bone disorder (CKD-MBD), intestinal gene expression, and oxidative stress.

METHODS: Male CKD rats (Cy/+) and normal littermates were fed 1 of 3 diets: AC 0.7% phosphorus grain-based diet for 28 weeks (AC); AC diet for 17 weeks followed by non-autoclaved (Non-AC) 0.7% phosphorus casein diet until 28 weeks (AC + Casein); or Non-AC diet for 16 weeks followed by a Non-AC purified diet until 30 weeks (Non-AC + Casein).

RESULTS: AC diets contained ~3× higher AGEs and levels varied depending on the location within the autoclave. Rats fed the AC and AC + Casein diets had higher total AGEs and oxidative stress, irrespective of kidney function. Kidney function was more severely compromised in CKD rats fed AC or AC + Casein compared to Non-AC + Casein. There was a disease-by-diet interaction for plasma phosphorus, parathyroid hormone, and c-terminal fibroblast growth factor-23, driven by high values in the CKD rats fed the AC + Casein diet. Compared to Non-AC + Casein, AC and AC + Casein-fed groups had increased expression of receptor of AGEs and intestinal NADPH oxidase dual oxidase-2, independent of kidney function.

CONCLUSIONS: Autoclaving rodent diets impacts the progression of CKD and CKD-MBD, highlighting the critical importance of standardizing diets in experiments.

Original language	English (US)
Pages (from-to)	381-389
Number of pages	9
Journal	American Journal of Nephrology
Volume	51
Issue number	5
DOIs	https://doi.org/10.1159/000506729
State	Published - May 1 2020

Bibliographical note

Funding Information:
A.B. has received honoraria from Amgen. S.M.M. has received grant funding from Amgen, Sanofi, Chugai, and Keryx and scientific advising fees from Amgen. All other authors have no conflicts of interest to declare.

Funding Information:
A.B. was supported by the National Institutes of Health T32AR065971. KMHG was supported by NIH K01DK102864. S.M.M. has received grant funding from Amgen, Sanofi, Chugai, and Keryx and scientific advising fees from Amgen and is supported by the Veterans Affairs Merit Award BX001471, and NIH R01DK11087103, P30AR072581. Purdue University rat data were from a study partially funded through a Showalter Research Trust award to K.M.H.G. Part of the results in this paper were presented at Kidney Week 2019.

Publisher Copyright:
© 2020 S. Karger AG, Basel.

Keywords

Advanced glycation end-products
Chronic kidney disease-mineral and bone disorder
Diet
Gastrointestinal
Oxidative stress

PubMed: MeSH publication types

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

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10.1159/000506729

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Biruete, A., Srinivasan, S., O'Neill, K. D., Vorland, C. J., Hill Gallant, K. M., Cai, W., Uribarri, J., Johnston, N., Allen, M. R., Chen, N. X., & Moe, S. M. (2020). Adverse Effects of Autoclaved Diets on the Progression of Chronic Kidney Disease and Chronic Kidney Disease-Mineral Bone Disorder in Rats. American Journal of Nephrology, 51(5), 381-389. https://doi.org/10.1159/000506729

Biruete, A, Srinivasan, S, O'Neill, KD, Vorland, CJ, Hill Gallant, KM, Cai, W, Uribarri, J, Johnston, N, Allen, MR, Chen, NX & Moe, SM 2020, 'Adverse Effects of Autoclaved Diets on the Progression of Chronic Kidney Disease and Chronic Kidney Disease-Mineral Bone Disorder in Rats', American Journal of Nephrology, vol. 51, no. 5, pp. 381-389. https://doi.org/10.1159/000506729

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title = "Adverse Effects of Autoclaved Diets on the Progression of Chronic Kidney Disease and Chronic Kidney Disease-Mineral Bone Disorder in Rats",

abstract = "BACKGROUND: Autoclaving rodent diets is common in laboratory animals, but autoclaving increases the formation of dietary advanced glycation end-products (AGE). We studied the effect of autoclaved (AC) diet alone or in combination with a diet high in bioavailable phosphorus on biochemistries of chronic kidney disease-mineral and bone disorder (CKD-MBD), intestinal gene expression, and oxidative stress.METHODS: Male CKD rats (Cy/+) and normal littermates were fed 1 of 3 diets: AC 0.7% phosphorus grain-based diet for 28 weeks (AC); AC diet for 17 weeks followed by non-autoclaved (Non-AC) 0.7% phosphorus casein diet until 28 weeks (AC + Casein); or Non-AC diet for 16 weeks followed by a Non-AC purified diet until 30 weeks (Non-AC + Casein).RESULTS: AC diets contained ~3× higher AGEs and levels varied depending on the location within the autoclave. Rats fed the AC and AC + Casein diets had higher total AGEs and oxidative stress, irrespective of kidney function. Kidney function was more severely compromised in CKD rats fed AC or AC + Casein compared to Non-AC + Casein. There was a disease-by-diet interaction for plasma phosphorus, parathyroid hormone, and c-terminal fibroblast growth factor-23, driven by high values in the CKD rats fed the AC + Casein diet. Compared to Non-AC + Casein, AC and AC + Casein-fed groups had increased expression of receptor of AGEs and intestinal NADPH oxidase dual oxidase-2, independent of kidney function.CONCLUSIONS: Autoclaving rodent diets impacts the progression of CKD and CKD-MBD, highlighting the critical importance of standardizing diets in experiments.",

keywords = "Advanced glycation end-products, Chronic kidney disease-mineral and bone disorder, Diet, Gastrointestinal, Oxidative stress",

author = "Annabel Biruete and Shruthi Srinivasan and O'Neill, {Kalisha D} and Vorland, {Colby J} and {Hill Gallant}, {Kathleen M} and Weijing Cai and Jaime Uribarri and Nancy Johnston and Allen, {Matthew R} and Chen, {Neal X} and Moe, {Sharon M}",

note = "Funding Information: A.B. has received honoraria from Amgen. S.M.M. has received grant funding from Amgen, Sanofi, Chugai, and Keryx and scientific advising fees from Amgen. All other authors have no conflicts of interest to declare. Funding Information: A.B. was supported by the National Institutes of Health T32AR065971. KMHG was supported by NIH K01DK102864. S.M.M. has received grant funding from Amgen, Sanofi, Chugai, and Keryx and scientific advising fees from Amgen and is supported by the Veterans Affairs Merit Award BX001471, and NIH R01DK11087103, P30AR072581. Purdue University rat data were from a study partially funded through a Showalter Research Trust award to K.M.H.G. Part of the results in this paper were presented at Kidney Week 2019. Publisher Copyright: {\textcopyright} 2020 S. Karger AG, Basel.",

year = "2020",

month = may,

day = "1",

doi = "10.1159/000506729",

language = "English (US)",

volume = "51",

pages = "381--389",

journal = "American Journal of Nephrology",

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publisher = "S. Karger AG",

number = "5",

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T1 - Adverse Effects of Autoclaved Diets on the Progression of Chronic Kidney Disease and Chronic Kidney Disease-Mineral Bone Disorder in Rats

AU - Biruete, Annabel

AU - Srinivasan, Shruthi

AU - O'Neill, Kalisha D

AU - Vorland, Colby J

AU - Hill Gallant, Kathleen M

AU - Cai, Weijing

AU - Uribarri, Jaime

AU - Johnston, Nancy

AU - Allen, Matthew R

AU - Chen, Neal X

AU - Moe, Sharon M

N1 - Funding Information: A.B. has received honoraria from Amgen. S.M.M. has received grant funding from Amgen, Sanofi, Chugai, and Keryx and scientific advising fees from Amgen. All other authors have no conflicts of interest to declare. Funding Information: A.B. was supported by the National Institutes of Health T32AR065971. KMHG was supported by NIH K01DK102864. S.M.M. has received grant funding from Amgen, Sanofi, Chugai, and Keryx and scientific advising fees from Amgen and is supported by the Veterans Affairs Merit Award BX001471, and NIH R01DK11087103, P30AR072581. Purdue University rat data were from a study partially funded through a Showalter Research Trust award to K.M.H.G. Part of the results in this paper were presented at Kidney Week 2019. Publisher Copyright: © 2020 S. Karger AG, Basel.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - BACKGROUND: Autoclaving rodent diets is common in laboratory animals, but autoclaving increases the formation of dietary advanced glycation end-products (AGE). We studied the effect of autoclaved (AC) diet alone or in combination with a diet high in bioavailable phosphorus on biochemistries of chronic kidney disease-mineral and bone disorder (CKD-MBD), intestinal gene expression, and oxidative stress.METHODS: Male CKD rats (Cy/+) and normal littermates were fed 1 of 3 diets: AC 0.7% phosphorus grain-based diet for 28 weeks (AC); AC diet for 17 weeks followed by non-autoclaved (Non-AC) 0.7% phosphorus casein diet until 28 weeks (AC + Casein); or Non-AC diet for 16 weeks followed by a Non-AC purified diet until 30 weeks (Non-AC + Casein).RESULTS: AC diets contained ~3× higher AGEs and levels varied depending on the location within the autoclave. Rats fed the AC and AC + Casein diets had higher total AGEs and oxidative stress, irrespective of kidney function. Kidney function was more severely compromised in CKD rats fed AC or AC + Casein compared to Non-AC + Casein. There was a disease-by-diet interaction for plasma phosphorus, parathyroid hormone, and c-terminal fibroblast growth factor-23, driven by high values in the CKD rats fed the AC + Casein diet. Compared to Non-AC + Casein, AC and AC + Casein-fed groups had increased expression of receptor of AGEs and intestinal NADPH oxidase dual oxidase-2, independent of kidney function.CONCLUSIONS: Autoclaving rodent diets impacts the progression of CKD and CKD-MBD, highlighting the critical importance of standardizing diets in experiments.

AB - BACKGROUND: Autoclaving rodent diets is common in laboratory animals, but autoclaving increases the formation of dietary advanced glycation end-products (AGE). We studied the effect of autoclaved (AC) diet alone or in combination with a diet high in bioavailable phosphorus on biochemistries of chronic kidney disease-mineral and bone disorder (CKD-MBD), intestinal gene expression, and oxidative stress.METHODS: Male CKD rats (Cy/+) and normal littermates were fed 1 of 3 diets: AC 0.7% phosphorus grain-based diet for 28 weeks (AC); AC diet for 17 weeks followed by non-autoclaved (Non-AC) 0.7% phosphorus casein diet until 28 weeks (AC + Casein); or Non-AC diet for 16 weeks followed by a Non-AC purified diet until 30 weeks (Non-AC + Casein).RESULTS: AC diets contained ~3× higher AGEs and levels varied depending on the location within the autoclave. Rats fed the AC and AC + Casein diets had higher total AGEs and oxidative stress, irrespective of kidney function. Kidney function was more severely compromised in CKD rats fed AC or AC + Casein compared to Non-AC + Casein. There was a disease-by-diet interaction for plasma phosphorus, parathyroid hormone, and c-terminal fibroblast growth factor-23, driven by high values in the CKD rats fed the AC + Casein diet. Compared to Non-AC + Casein, AC and AC + Casein-fed groups had increased expression of receptor of AGEs and intestinal NADPH oxidase dual oxidase-2, independent of kidney function.CONCLUSIONS: Autoclaving rodent diets impacts the progression of CKD and CKD-MBD, highlighting the critical importance of standardizing diets in experiments.

KW - Advanced glycation end-products

KW - Chronic kidney disease-mineral and bone disorder

KW - Diet

KW - Gastrointestinal

KW - Oxidative stress

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DO - 10.1159/000506729

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SN - 0250-8095

VL - 51

SP - 381

EP - 389

JO - American Journal of Nephrology

JF - American Journal of Nephrology

IS - 5

ER -

Adverse Effects of Autoclaved Diets on the Progression of Chronic Kidney Disease and Chronic Kidney Disease-Mineral Bone Disorder in Rats

Abstract

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Keywords

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