Advancing organ cryopreservation through scalable polymer coating of iron oxide nanoparticles

Jacqueline l. Pasek-Allen; Zhe Gao; Randall k. Wilharm; Valerie c. Pierre; John c. Bischof

doi:10.1016/j.cryobiol.2022.11.067

Advancing organ cryopreservation through scalable polymer coating of iron oxide nanoparticles

Jacqueline l. Pasek-Allen, Zhe Gao, Randall k. Wilharm, Valerie c. Pierre, John c. Bischof

Research output: Contribution to journal › Conference article › peer-review

Abstract

Using radiofrequency excited iron oxide nanoparticles (IONPs) dispersed in cryoprotective agents (CPAs), we have successfully rewarmed vitrified, cryopreserved (-150oC) biological samples. Previous IONPs, our silica coated sIONP, have limited Fe saturation concentration in CPA. We present a small molecule phosphonate linker (PLink) IONP coating method that is CPA stable, improves saturation concentration, and inexpensive for scale-up (> 1g).

Original language	English (US)
Pages (from-to)	21
Journal	Cryobiology
Volume	109
DOIs	https://doi.org/10.1016/j.cryobiol.2022.11.067
State	Published - Dec 1 2022

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10.1016/j.cryobiol.2022.11.067

https://linkinghub.elsevier.com/retrieve/pii/S0011224022001821

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title = "Advancing organ cryopreservation through scalable polymer coating of iron oxide nanoparticles",

abstract = "Using radiofrequency excited iron oxide nanoparticles (IONPs) dispersed in cryoprotective agents (CPAs), we have successfully rewarmed vitrified, cryopreserved (-150oC) biological samples. Previous IONPs, our silica coated sIONP, have limited Fe saturation concentration in CPA. We present a small molecule phosphonate linker (PLink) IONP coating method that is CPA stable, improves saturation concentration, and inexpensive for scale-up (> 1g).",

author = "Pasek-Allen, \{Jacqueline l.\} and Zhe Gao and Wilharm, \{Randall k.\} and Pierre, \{Valerie c.\} and Bischof, \{John c.\}",

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doi = "10.1016/j.cryobiol.2022.11.067",

language = "English (US)",

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TY - JOUR

T1 - Advancing organ cryopreservation through scalable polymer coating of iron oxide nanoparticles

AU - Pasek-Allen, Jacqueline l.

AU - Gao, Zhe

AU - Wilharm, Randall k.

AU - Pierre, Valerie c.

AU - Bischof, John c.

PY - 2022/12/1

Y1 - 2022/12/1

N2 - Using radiofrequency excited iron oxide nanoparticles (IONPs) dispersed in cryoprotective agents (CPAs), we have successfully rewarmed vitrified, cryopreserved (-150oC) biological samples. Previous IONPs, our silica coated sIONP, have limited Fe saturation concentration in CPA. We present a small molecule phosphonate linker (PLink) IONP coating method that is CPA stable, improves saturation concentration, and inexpensive for scale-up (> 1g).

AB - Using radiofrequency excited iron oxide nanoparticles (IONPs) dispersed in cryoprotective agents (CPAs), we have successfully rewarmed vitrified, cryopreserved (-150oC) biological samples. Previous IONPs, our silica coated sIONP, have limited Fe saturation concentration in CPA. We present a small molecule phosphonate linker (PLink) IONP coating method that is CPA stable, improves saturation concentration, and inexpensive for scale-up (> 1g).

U2 - 10.1016/j.cryobiol.2022.11.067

DO - 10.1016/j.cryobiol.2022.11.067

M3 - Conference article

SN - 0011-2240

VL - 109

SP - 21

JO - Cryobiology

JF - Cryobiology

ER -

Advancing organ cryopreservation through scalable polymer coating of iron oxide nanoparticles

Abstract

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