Advances in understanding bone cancer pain

M. J. Goblirsch, P. Zwolak, D. R. Clohisy

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Experimental animal models of bone cancer pain have emerged and findings have provided a unique glimpse into unraveling the mechanism that drives this debilitating condition. Key contributors to the generation and maintenance of bone cancer pain are tumor-induced osteolysis, tumor itself, and production of nociceptive mediators in the bone-tumor microenvironment.

Original languageEnglish (US)
Pages (from-to)682-688
Number of pages7
JournalJournal of Cellular Biochemistry
Issue number4
StatePublished - Nov 1 2005


  • Bone cancer
  • Experimental model
  • Neurochemical markers
  • Osteolysis
  • Pain


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