Advances in understanding bone cancer pain

Michael J Goblirsch, P. Zwolak, Denis R Clohisy

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Experimental animal models of bone cancer pain have emerged and findings have provided a unique glimpse into unraveling the mechanism that drives this debilitating condition. Key contributors to the generation and maintenance of bone cancer pain are tumor-induced osteolysis, tumor itself, and production of nociceptive mediators in the bone-tumor microenvironment.

Original languageEnglish (US)
Pages (from-to)682-688
Number of pages7
JournalJournal of Cellular Biochemistry
Volume96
Issue number4
DOIs
StatePublished - Nov 1 2005

Keywords

  • Bone cancer
  • Experimental model
  • Neurochemical markers
  • Osteolysis
  • Pain

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