Abstract
Experimental animal models of bone cancer pain have emerged and findings have provided a unique glimpse into unraveling the mechanism that drives this debilitating condition. Key contributors to the generation and maintenance of bone cancer pain are tumor-induced osteolysis, tumor itself, and production of nociceptive mediators in the bone-tumor microenvironment.
Original language | English (US) |
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Pages (from-to) | 682-688 |
Number of pages | 7 |
Journal | Journal of Cellular Biochemistry |
Volume | 96 |
Issue number | 4 |
DOIs | |
State | Published - Nov 1 2005 |
Keywords
- Bone cancer
- Experimental model
- Neurochemical markers
- Osteolysis
- Pain