Advances in thrombolytics and mechanical devices for treatment of acute ischemic stroke

Ammar Alkawi, Jawad F. Kirmani, Nazli Janjua, Ismail Khatri, Shafiuddin Ahmed, Afshin A. Divani, Adrian I. Qureshi

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Stroke is a leading cause of death and disability. Recently, there have been advances in the treatment of acute ischemic stroke aimed at re-establishing blood flow to the affected area in an effort to save the ischemic penumbra surrounding the area of infarction. This is achieved by the use of thrombolytics intravenously or intra-arterially. The use of mechanical devices facilitates the function of pharmacological agents used in addition to minimizing the associated risks. In this review, we first discuss the therapeutic potentials and strategies employed in using different thrombolytics in management of acute ischemic stroke. Subsequently, we discuss the recent advances and therapeutic applications of mechanical devices in this field.

Original languageEnglish (US)
JournalNeurological Research
Volume27
Issue numberSUPPL. 1
DOIs
StatePublished - Oct 1 2005

Keywords

  • Mechanical devices
  • Recanalization
  • Stents
  • Stroke
  • Thrombolytics

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