Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries

Clemencia Pinilla, Jon R. Appel, Eva Borràs, Richard A. Houghten

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations

Abstract

The conceptual and technical approaches that led to the explosive growth of combinatorial chemistry began approximately 20 years ago. In the past decade, combinatorial chemistry has continued to expand with new chemistries, technological improvements and, most importantly, a clear demonstration of its utility in the identification of active compounds for research and drug-discovery programs. This article describes the conceptual and practical breakthroughs that have been critical for the development of synthetic combinatorial methods and includes the most recent developments and applications of mixture-based combinatorial libraries.

Original languageEnglish (US)
Pages (from-to)118-122
Number of pages5
JournalNature Medicine
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

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