Advances in the support of respiratory failure: Putting all the evidence together

John J. Marini

doi:10.1186/cc14722

Advances in the support of respiratory failure: Putting all the evidence together

John J. Marini

Pulmonary, Allergy, Critical Care and Sleep Medicine

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Considerable progress has been made recently in the understanding of how best to accomplish safe and effective ventilation of patients with acute lung injury. Mechanical and nonmechanical factors contribute to causation of ventilator-associated lung injury. Intervention timing helps determine the therapeutic efficacy and outcome, and the stage and severity of the disease process may determine the patient's vulnerability as well as an intervention's value. Reducing oxygen consumption and ventilatory demands are key to a successful strategy for respiratory support of acute respiratory distress syndrome. Results from major clinical trials can be understood against the background of the complex physiology of ventilator-induced lung injury.

Original language	English (US)
Article number	S4
Journal	Critical Care
Volume	19
DOIs	https://doi.org/10.1186/cc14722
State	Published - Dec 18 2015

Bibliographical note

Funding Information:
The author declares that he has no competing interests. This article has been published as part of Critical Care Volume 19 Supplement 3, 2015: Future of Critical Care Medicine (FCCM) 2014. The full contents of the supplement are available online at http://www.ccforum. com/supplements/19/S3. Publication of this supplement was supported by Fresenius Kabi.

Publisher Copyright:
© 2015 Marini.

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title = "Advances in the support of respiratory failure: Putting all the evidence together",

abstract = "Considerable progress has been made recently in the understanding of how best to accomplish safe and effective ventilation of patients with acute lung injury. Mechanical and nonmechanical factors contribute to causation of ventilator-associated lung injury. Intervention timing helps determine the therapeutic efficacy and outcome, and the stage and severity of the disease process may determine the patient's vulnerability as well as an intervention's value. Reducing oxygen consumption and ventilatory demands are key to a successful strategy for respiratory support of acute respiratory distress syndrome. Results from major clinical trials can be understood against the background of the complex physiology of ventilator-induced lung injury.",

author = "Marini, {John J.}",

note = "Funding Information: The author declares that he has no competing interests. This article has been published as part of Critical Care Volume 19 Supplement 3, 2015: Future of Critical Care Medicine (FCCM) 2014. The full contents of the supplement are available online at http://www.ccforum. com/supplements/19/S3. Publication of this supplement was supported by Fresenius Kabi. Publisher Copyright: {\textcopyright} 2015 Marini.",

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PY - 2015/12/18

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N2 - Considerable progress has been made recently in the understanding of how best to accomplish safe and effective ventilation of patients with acute lung injury. Mechanical and nonmechanical factors contribute to causation of ventilator-associated lung injury. Intervention timing helps determine the therapeutic efficacy and outcome, and the stage and severity of the disease process may determine the patient's vulnerability as well as an intervention's value. Reducing oxygen consumption and ventilatory demands are key to a successful strategy for respiratory support of acute respiratory distress syndrome. Results from major clinical trials can be understood against the background of the complex physiology of ventilator-induced lung injury.

AB - Considerable progress has been made recently in the understanding of how best to accomplish safe and effective ventilation of patients with acute lung injury. Mechanical and nonmechanical factors contribute to causation of ventilator-associated lung injury. Intervention timing helps determine the therapeutic efficacy and outcome, and the stage and severity of the disease process may determine the patient's vulnerability as well as an intervention's value. Reducing oxygen consumption and ventilatory demands are key to a successful strategy for respiratory support of acute respiratory distress syndrome. Results from major clinical trials can be understood against the background of the complex physiology of ventilator-induced lung injury.

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Advances in the support of respiratory failure: Putting all the evidence together

Abstract

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