Mosquitoes are a problem in temperate and tropical zones of the world. The adult female requires vertebrate blood for her eggs to develop and seeks a host soon after emergence. During the blood meal, a variety of human and animal pathogens may be exchanged between host and mosquito, including viruses, bacteria, protozoa, and filarial worms. Unfortunately, the relationship between vector and pathogen is in most cases poorly understood because of a lack of suitable in vitro culture systems. We use mosquito cells to study the metabolic characteristics of these invertebrates at the cellular level and their relationship with mosquito-borne protozoan parasites. We are working mainly with two cell lines: one, ASE-1V, isolated by us from a vector of malaria, Anopheles stephensi; 1 the other, TAE-12V, isolated from a nonbiting mosquito, Toxorhynchites amboinensis.
|Title of host publication
|Invertebrate Cell System Applications
|Subtitle of host publication
|Number of pages
|Published - Jan 1 2018