Advances in Neonatal Extracorporeal Support. The Role of Extracorporeal Membrane Oxygenation and the Artificial Placenta

Brian W. Gray; Andrew W. Shaffer; George B. Mychaliska

doi:10.1016/j.clp.2012.04.006

Advances in Neonatal Extracorporeal Support. The Role of Extracorporeal Membrane Oxygenation and the Artificial Placenta

Brian W. Gray, Andrew W. Shaffer, George B. Mychaliska

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

This review addresses the history and evolution of neonatal extracorporeal membrane oxygenation (ECMO), with a discussion of the indications, contraindications, modalities, outcomes, and impact of ECMO. Controversies surrounding novel uses of ECMO in neonates, namely ECMO for premature infants and ex utero intrapartum therapy with transition to ECMO, are discussed. The development of an extracorporeal artificial placenta for support of premature infants is presented, including the rationale, research, and challenges. ECMO has had a dramatic effect on the care of critically ill neonates over the past 4 decades, and there is great potential to expand these benefits in the future.

Original language	English (US)
Pages (from-to)	311-329
Number of pages	19
Journal	Clinics in Perinatology
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/j.clp.2012.04.006
State	Published - Jun 2012
Externally published	Yes

Keywords

Artificial placenta
Cardiac failure
ECMO
EXIT to ECMO
Extracorporeal life support
Extracorporeal membrane oxygenation
Neonatal
Prematurity
Respiratory failure

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10.1016/j.clp.2012.04.006

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abstract = "This review addresses the history and evolution of neonatal extracorporeal membrane oxygenation (ECMO), with a discussion of the indications, contraindications, modalities, outcomes, and impact of ECMO. Controversies surrounding novel uses of ECMO in neonates, namely ECMO for premature infants and ex utero intrapartum therapy with transition to ECMO, are discussed. The development of an extracorporeal artificial placenta for support of premature infants is presented, including the rationale, research, and challenges. ECMO has had a dramatic effect on the care of critically ill neonates over the past 4 decades, and there is great potential to expand these benefits in the future.",

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AU - Shaffer, Andrew W.

AU - Mychaliska, George B.

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AB - This review addresses the history and evolution of neonatal extracorporeal membrane oxygenation (ECMO), with a discussion of the indications, contraindications, modalities, outcomes, and impact of ECMO. Controversies surrounding novel uses of ECMO in neonates, namely ECMO for premature infants and ex utero intrapartum therapy with transition to ECMO, are discussed. The development of an extracorporeal artificial placenta for support of premature infants is presented, including the rationale, research, and challenges. ECMO has had a dramatic effect on the care of critically ill neonates over the past 4 decades, and there is great potential to expand these benefits in the future.

KW - Artificial placenta

KW - Cardiac failure

KW - ECMO

KW - EXIT to ECMO

KW - Extracorporeal life support

KW - Extracorporeal membrane oxygenation

KW - Neonatal

KW - Prematurity

KW - Respiratory failure

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Advances in Neonatal Extracorporeal Support. The Role of Extracorporeal Membrane Oxygenation and the Artificial Placenta

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