Advances in Machine Learning for SERS Analysis

Tip-Enhanced Raman Scattering (TERS) has emerged as a revolutionary technique capable of probing matter at the nanoscale, offering unprecedented spatial resolution and sensitivity. This chapter provides a comprehensive overview of the recent advancements in TERS, highlighting its pivotal role in various scientific disciplines. We begin by tracing the historical development of TERS and discuss the significant breakthroughs that have propelled its progress. Subsequently, we delve into the unique capabilities of TERS in studying single molecules, unraveling the intricacies of nanostructures, and exploring the nanoscale properties of materials. The application of TERS in the realm of biomolecular research is also explored, shedding light on its potential to elucidate fundamental biological processes. Furthermore, the chapter addresses the ongoing development of TERS instrumentation, discussing innovative approaches to enhance sensitivity, spatial resolution, and versatility. We highlight the challenges and opportunities that lie ahead in the field of TERS, emphasizing its potential to drive future discoveries in nanoscience and related fields.