Advances in Development and Application of Influenza Vaccines

Jidang Chen, Jiehuang Wang, Jipei Zhang, Hinh Ly

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Influenza A virus is one of the most important zoonotic pathogens that can cause severe symptoms and has the potential to cause high number of deaths and great economic loss. Vaccination is still the best option to prevent influenza virus infection. Different types of influenza vaccines, including live attenuated virus vaccines, inactivated whole virus vaccines, virosome vaccines, split-virion vaccines and subunit vaccines have been developed. However, they have several limitations, such as the relatively high manufacturing cost and long production time, moderate efficacy of some of the vaccines in certain populations, and lack of cross-reactivity. These are some of the problems that need to be solved. Here, we summarized recent advances in the development and application of different types of influenza vaccines, including the recent development of viral vectored influenza vaccines. We also described the construction of other vaccines that are based on recombinant influenza viruses as viral vectors. Information provided in this review article might lead to the development of safe and highly effective novel influenza vaccines.

Original languageEnglish (US)
Article number711997
JournalFrontiers in immunology
StatePublished - Jul 13 2021

Bibliographical note

Funding Information:
This study was supported by the National Natural Science Foundation of China (NSFC) (grant number 31800141), the Natural Science Foundation of Guangdong Province, China (grant number 2017A030310573), the Rural Revitalization Strategy Special Foundation of Guangdong Province (Rural Science and Technology Commissioner Program) (grant number 163-2019-XMZC-0009-02-0075), and Key Research Program of Education Department of Guangdong Province (grant number 2020ZDZX1018).

Publisher Copyright:
© Copyright © 2021 Chen, Wang, Zhang and Ly.


  • influenza vaccines
  • seasonal influenza vaccine strains selection
  • subunit vaccines
  • universal influenza vaccines development
  • viral vectored vaccines

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review


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