TY - JOUR
T1 - Advances in Deep Brain Stimulation
T2 - From Mechanisms to Applications
AU - Sandoval-Pistorius, Stephanie S.
AU - Hacker, Mallory L.
AU - Waters, Allison C.
AU - Wang, Jing
AU - Provenza, Nicole R.
AU - de Hemptinne, Coralie
AU - Johnson, Kara A.
AU - Morrison, Melanie A.
AU - Cernera, Stephanie
N1 - Publisher Copyright:
Copyright © 2023 the authors.
PY - 2023/11/8
Y1 - 2023/11/8
N2 - Deep brain stimulation (DBS) is an effective therapy for various neurologic and neuropsychiatric disorders, involving chronic implantation of electrodes into target brain regions for electrical stimulation delivery. Despite its safety and efficacy, DBS remains an underutilized therapy. Advances in the field of DBS, including in technology, mechanistic understanding, and applications have the potential to expand access and use of DBS, while also improving clinical outcomes. Developments in DBS technology, such as MRI compatibility and bidirectional DBS systems capable of sensing neural activity while providing therapeutic stimulation, have enabled advances in our understanding of DBS mechanisms and its application. In this review, we summarize recent work exploring DBS modulation of target networks. We also cover current work focusing on improved programming and the development of novel stimulation paradigms that go beyond current standards of DBS, many of which are enabled by sensing-enabled DBS systems and have the potential to expand access to DBS.
AB - Deep brain stimulation (DBS) is an effective therapy for various neurologic and neuropsychiatric disorders, involving chronic implantation of electrodes into target brain regions for electrical stimulation delivery. Despite its safety and efficacy, DBS remains an underutilized therapy. Advances in the field of DBS, including in technology, mechanistic understanding, and applications have the potential to expand access and use of DBS, while also improving clinical outcomes. Developments in DBS technology, such as MRI compatibility and bidirectional DBS systems capable of sensing neural activity while providing therapeutic stimulation, have enabled advances in our understanding of DBS mechanisms and its application. In this review, we summarize recent work exploring DBS modulation of target networks. We also cover current work focusing on improved programming and the development of novel stimulation paradigms that go beyond current standards of DBS, many of which are enabled by sensing-enabled DBS systems and have the potential to expand access to DBS.
KW - coordinated reset
KW - deep brain stimulation
KW - evoked potentials
KW - functional magnetic resonance imaging
KW - sweet spot mapping
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U2 - 10.1523/JNEUROSCI.1427-23.2023
DO - 10.1523/JNEUROSCI.1427-23.2023
M3 - Article
C2 - 37940596
AN - SCOPUS:85176440692
SN - 0270-6474
VL - 43
SP - 7575
EP - 7586
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 45
ER -