Advances in clinical NK cell studies: Donor selection, manufacturing and quality control

U. Koehl, C. Kalberer, J. Spanholtz, D. A. Lee, J. S. Miller, S. Cooley, M. Lowdell, L. Uharek, H. Klingemann, A. Curti, W. Leung, E. Alici

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations


ABSTRACT: Natural killer (NK) cells are increasingly used in clinical studies in order to treat patients with various malignancies. The following review summarizes platform lectures and 2013–2015 consortium meetings on manufacturing and clinical use of NK cells in Europe and United States. A broad overview of recent pre-clinical and clinical results in NK cell therapies is provided based on unstimulated, cytokine-activated, as well as genetically engineered NK cells using chimeric antigen receptors (CAR). Differences in donor selection, manufacturing and quality control of NK cells for cancer immunotherapies are described and basic recommendations are outlined for harmonization in future NK cell studies.

Original languageEnglish (US)
Issue number4
StatePublished - Apr 2 2016

Bibliographical note

Publisher Copyright:
© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC


  • Clinical NK cell studies
  • ex vivo expansion
  • manufacturing of NK cell products
  • quality control


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