Advances in cellular and humoral immunotherapy – implications for the treatment of poor risk childhood, adolescent, and young adult B-cell non-Hodgkin lymphoma

Yaya Chu, Aliza Gardenswartz, Amanda Termuhlen, Mitchell S. Cairo

Research output: Contribution to journalArticle

Abstract

Patients with relapsed, refractory or advanced stage B non-Hodgkin lymphoma (NHL) continue to have a dismal prognosis. This review summarises current and novel cellular and immunotherapy for these high-risk populations, including haematopoietic stem cell transplant, bispecific antibodies, viral-derived cytotoxic T cells, chimeric antigen receptor (CAR) T cells, and natural killer (NK) cell therapy, as discussed at the 6th International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma on September 26th–29th 2018 in Rotterdam, the Netherlands, and explores the future of NK/CAR NK therapies.

LanguageEnglish (US)
JournalBritish Journal of Haematology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Immunotherapy
Young Adult
Bispecific Antibodies
Antigen Receptors
Cell- and Tissue-Based Therapy
Hematopoietic Stem Cells
T-Cell Antigen Receptor
Hodgkin Disease
Natural Killer Cells
Netherlands
T-Lymphocytes
Transplants
Therapeutics
Population

Keywords

  • B-cell non-Hodgkin lymphoma
  • IL-15 superagonist
  • cellular immunotherapy
  • chimeric antigen receptor
  • stem cell transplantation

Cite this

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