Advances and challenges in transcranial magnetic stimulation (TMS) research on motor systems

Mo Chen, Christopher C. Cline, Kate L. Frost, Teresa J. Kimberley, Samuel T. Nemanich, Bernadette T. Gillick, Cristina S. Albott, Cecilia N. Prudente, Kelvin O. Lim, Bin He

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Transcranial magnetic stimulation (TMS) is a technique for noninvasive brain stimulation to modulate function, with a range of applications across neuroscience research and the clinical management of brain disorders. Currently, there are two major categories of applied TMS paradigms: (1) the application of single pulses with high temporal precision for brain mapping and various diagnostic objectives and (2) neural stimulation with trains of repeated pulses to alter cortical excitability, primarily for therapeutic purposes. Recently, exploration of noninvasive neuromodulation has increased considerably in both scientific and clinical research fields. The unique capabilities to both assess and change brain circuits noninvasively have made TMS a widely adopted and fast-growing applied methodology in neuromodulation. This chapter reviews recent advances, challenges, and future trends in the field of TMS as applied to the human motor systems.

Original languageEnglish (US)
Title of host publicationEngineering in Medicine
Subtitle of host publicationAdvances and Challenges
Number of pages36
ISBN (Electronic)9780128130681
ISBN (Print)9780128135143
StatePublished - Jan 1 2018

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc. All rights reserved.


  • Motor cortex excitability
  • Neuromodulation
  • Neuronavigation
  • Repetitive transcranial magnetic stimulation
  • TMS
  • Transcranial magnetic stimulation
  • rTMS


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