Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

Cameron McDonald-Hyman; Laurence A. Turka; Bruce R. Blazar

doi:10.1126/scitranslmed.aaa6853

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

Research output: Contribution to journal › Review article › peer-review

Abstract

Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.

Original language	English (US)
Article number	280rv2
Journal	Science Translational Medicine
Volume	7
Issue number	280
DOIs	https://doi.org/10.1126/scitranslmed.aaa6853
State	Published - Mar 25 2015

Bibliographical note

Publisher Copyright:
© 2015, AAAS. All rights reserved.

Publisher link

10.1126/scitranslmed.aaa6853

Find It

Find It at U of M Libraries

Cite this

@article{f8ce623f508244b1ae152a67ddac926d,

title = "Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation",

abstract = "Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.",

author = "Cameron McDonald-Hyman and Turka, \{Laurence A.\} and Blazar, \{Bruce R.\}",

year = "2015",

month = mar,

day = "25",

doi = "10.1126/scitranslmed.aaa6853",

language = "English (US)",

volume = "7",

journal = "Science Translational Medicine",

issn = "1946-6234",

publisher = "American Association for the Advancement of Science",

number = "280",

}

TY - JOUR

T1 - Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

AU - McDonald-Hyman, Cameron

AU - Turka, Laurence A.

AU - Blazar, Bruce R.

PY - 2015/3/25

Y1 - 2015/3/25

N2 - Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.

AB - Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.

UR - https://www.scopus.com/pages/publications/84925665321

UR - https://www.scopus.com/pages/publications/84925665321#tab=citedBy

U2 - 10.1126/scitranslmed.aaa6853

DO - 10.1126/scitranslmed.aaa6853

M3 - Review article

C2 - 25810312

AN - SCOPUS:84925665321

SN - 1946-6234

VL - 7

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 280

M1 - 280rv2

ER -

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

Abstract

Bibliographical note

Publisher link

Find It

Other files and links

Fingerprint

Cite this