Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

Cameron McDonald-Hyman; Laurence A. Turka; Bruce R. Blazar

doi:10.1126/scitranslmed.aaa6853

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

Cameron McDonald-Hyman, Laurence A. Turka, Bruce R. Blazar

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

Abstract

Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.

Original language	English (US)
Article number	280rv2
Journal	Science Translational Medicine
Volume	7
Issue number	280
DOIs	https://doi.org/10.1126/scitranslmed.aaa6853
State	Published - Mar 25 2015

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abstract = "Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.",

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AB - Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.

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JO - Science Translational Medicine

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Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

Abstract

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