Advancements in murine models of human gastric cancer

Jasneet Singh Bhullar, Neha Varshney, Vijay K. Mittal

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Murine models of gastric carcinogenesis are an in vivo tool essential for understanding the mechanisms of pathogenesis and search of better treatments. Over the years considerable changes in the understanding of the murine models of human gastric cancer have resulted in numerous models being reported in the literature. The gastric cancer transgenic mice and human xenograft heterotopic murine models were reported initially. These were followed by orthotopic tumor models which were found to be more relevant in portraying the human disease process as opposed to heterotopic models. Over time many techniques for making orthotopic gastric murine models were reported, each trying to overcome the drawbacks of the previously reported models. Although all of these models have their advantages and limitations, the latest orthotopic murine models seem to more accurately represent and replicate the human disease process. We discuss the different human gastric cancer murine models, their background, the techniques of creating them along with their advantages and limitations. Some of the studies in which human gastric murine models have been used are also briefly discussed. This extensive overview and details of an array of different resources in this field offer researchers a wide choice to choose a model which is more applicable to the type of study being planned.

Original languageEnglish (US)
Title of host publicationGastric Cancer
Subtitle of host publicationRisk Factors, Treatment and Clinical Outcomes
PublisherNova Science Publishers, Inc.
Pages125-140
Number of pages16
ISBN (Electronic)9781631179907
ISBN (Print)9781631179839
StatePublished - Jul 1 2014

Keywords

  • Animals
  • Her2/neu receptor
  • animal model
  • chemoprevention
  • diagnostic use;chemoprevention
  • diet
  • diet disease models
  • gastric cancer
  • gastric cancer-carcinogenesis
  • gastric neoplasms
  • heterotopic model
  • mice
  • min-mice
  • mouse
  • murine
  • murine model
  • mutant strains
  • orthotopic model
  • prevention and control
  • stomach cancer
  • therapeutic use
  • xenograft

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