Advancement in bioprocess technology: parallels between microbial natural products and cell culture biologics

Arpan A. Bandyopadhyay, Anurag Khetan, Li Hong Malmberg, Weichang Zhou, Wei Shou Hu

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

The emergence of natural products and industrial microbiology nearly eight decades ago propelled an era of bioprocess innovation. Half a century later, recombinant protein technology spurred the tremendous growth of biologics and added mammalian cells to the forefront of industrial producing cells in terms of the value of products generated. This review highlights the process technology of natural products and protein biologics. Despite the separation in time, there is a remarkable similarity in their progression. As the new generation of therapeutics for gene and cell therapy emerges, its process technology development can take inspiration from that of natural products and biologics.

Original languageEnglish (US)
Pages (from-to)785-797
Number of pages13
JournalJournal of Industrial Microbiology and Biotechnology
Volume44
Issue number4-5
DOIs
StatePublished - May 1 2017

Keywords

  • Natural products
  • Process technology
  • Protein biologics

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