Abstract
The emergence of natural products and industrial microbiology nearly eight decades ago propelled an era of bioprocess innovation. Half a century later, recombinant protein technology spurred the tremendous growth of biologics and added mammalian cells to the forefront of industrial producing cells in terms of the value of products generated. This review highlights the process technology of natural products and protein biologics. Despite the separation in time, there is a remarkable similarity in their progression. As the new generation of therapeutics for gene and cell therapy emerges, its process technology development can take inspiration from that of natural products and biologics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 785-797 |
| Number of pages | 13 |
| Journal | Journal of Industrial Microbiology and Biotechnology |
| Volume | 44 |
| Issue number | 4-5 |
| DOIs | |
| State | Published - May 1 2017 |
Bibliographical note
Publisher Copyright:© 2017, Society for Industrial Microbiology and Biotechnology.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
Keywords
- Natural products
- Process technology
- Protein biologics
