Abstract
Heart transplantation carries significant risks for the recipient in the peri- and postoperative period. These include primary graft dysfunction (PGD), right ventricular (RV) failure, rejection, and infectious complications. Allograft ischemia-reperfusion and recipient pulmonary hypertension are common causes of PGD and RV failure. The use of inotropes, pulmonary vasodilators, and mechanical circulatory support (MCS) for the management of these issues is common. Early acute rejection is typically characterized by allograft dysfunction and is most commonly diagnosed by endomyocardial biopsy. Depending on the severity of presentation, management of acute rejection ranges from short-term corticosteroid therapy to MCS. Infectious complications are also a significant source of early morbidity and mortality in heart transplant recipients.
| Original language | English (US) |
|---|---|
| Title of host publication | Congestive Heart Failure and Cardiac Transplantation |
| Subtitle of host publication | Clinical, Pathology, Imaging and Molecular Profiles |
| Publisher | Springer International Publishing |
| Pages | 493-504 |
| Number of pages | 12 |
| ISBN (Electronic) | 9783319445779 |
| ISBN (Print) | 9783319445755 |
| DOIs | |
| State | Published - Jun 1 2017 |
Bibliographical note
Publisher Copyright:© Springer International Publishing AG 2017.
Keywords
- Acute cellular rejection
- Antibody-mediated rejection
- Heart transplantation
- Hyperacute rejection
- Infection
- Mechanical circulatory support
- Primary graft dysfunction
- Right ventricular failure
- Size mismatch
