Objective: Most patients with childhood-onset growth hormone deficiency (CO-GHD) receive treatment with exogenous growth hormone (GH) to facilitate the attainment of their full potential adult height. Recent evidence suggests that continuing GH administration during the transition period between the end of linear growth and full adult maturity is necessary for proper body composition and bone and muscle health, and may also have beneficial effects on metabolic parameters, bone mineral density, and quality of life. The timing of this transition period coincides with the transfer of care from a pediatric to an adult endocrinologist, creating the potential for a care gap as a consequence of losing the patient to follow-up. Design: An advisory board comprising both pediatric and adult endocrinologists was assembled to address current clinical unmet needs and to collaborate on a structured transitional plan for optimal management of patients with CO-GHD. Insights/conclusion: The advisors suggest collaborative, multidisciplinary approaches to ensure continuity of care; ongoing testing and monitoring of GHD status into adulthood; and a clearly structured protocol that includes practical guidance for clinicians to establish best practices for transitioning older adolescents with persistent CO-GHD to adult care.
Bibliographical noteFunding Information:
NAT received institution-directed research grants from Ipsen and Novartis and served on advisory boards for Novo Nordisk and Strongbridge.
BSM has been a consultant for Ascendis, BioMarin, Bluebird Bio, GeneScience, Novo Nordisk, Pfizer, Sandoz, Sanofi Genzyme, Soleno, Takeda, and Tolmar and has received research support from AbbVie , Alexion , Novo Nordisk , OPKO , Orphan Reach , Sandoz , Sanofi Genzyme , and Takeda .
The advisory board was sponsored by and was held at Novo Nordisk Inc. , Plainsboro, NJ.
© 2020 The Authors
- Adult endocrinologist
- Childhood-onset growth hormone deficiency
- Growth hormone replacement
- Pediatric endocrinologist
- Transition of care
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't