Adrenocorticotropin-containing neoplastic cells in a pars intermedia adenoma in a horse.

C. J. Horvath, T. R. Ames, A. L. Metz, V. L. Larson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Pituitary-dependent hyperadrenocorticism was diagnosed in a 14-year-old Arabian mare with chronic weight loss, hirsutism, polyuria, and polydipsia. The mare had a stress leukogram, glucosuria, and consistent hyperglycemia. Plasma glucose concentrations were resistant to suppression by insulin. Plasma cortisol concentrations were within normal limits, but did not respond to dexamethasone suppression and had an exaggerated response to ACTH stimulation. At necropsy, a chromophobe adenoma of the pars intermedia of the pituitary gland was found. The zona fasciculata of the adrenal cortex and the pancreatic islets of Langerhans were hypertrophied. An immunohistologic staining technique was used to demonstrate ACTH-containing neoplastic cells in the pituitary mass. These cells released ACTH and other peptides that initiated the chain of endocrinologic events leading to clinical disease.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalJournal of the American Veterinary Medical Association
Issue number3
StatePublished - Feb 1 1988


Dive into the research topics of 'Adrenocorticotropin-containing neoplastic cells in a pars intermedia adenoma in a horse.'. Together they form a unique fingerprint.

Cite this