Adrenergic denervation of guinea pig trachea with 6-hydroxydopamine

T. McGowan; Dennis E Niewoehner

doi:10.1007/BF02713707

Adrenergic denervation of guinea pig trachea with 6-hydroxydopamine

T. McGowan, Dennis E Niewoehner

Medicine - Veteran's Administration Medical Center

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Abstract

We studied adrenergic nerve morphology and function in guinea pig trachea in relationship to dose and time after administration of 6-hydroxy dopamine (6-OHDA). At one day after maximally tolerated doses (400 mg/kg on two or five successive days) adrenergic nerve histofluorescence was abolished. Histofluorescence was again visible at eight days after treatment and was indistinguishable from controls at 30 days, a pattern also observed in heart and iris. In isolated tracheal segments from treated animals there was suppression of³H-norepinephrine uptake, supersensitivity to applied norepinephrine, and a decrease in the adrenergic component of electrical stimulation-induced relaxation. We conclude that 6-OHDA is effective in producing fairly complete, but transient, adrenergic denervation of guinea pig airways.

Original language	English (US)
Pages (from-to)	81-89
Number of pages	9
Journal	Lung
Volume	158
Issue number	1
DOIs	https://doi.org/10.1007/BF02713707
State	Published - Dec 1980

Keywords

6-hydroxydopamine
Adrenergic denervation

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abstract = "We studied adrenergic nerve morphology and function in guinea pig trachea in relationship to dose and time after administration of 6-hydroxy dopamine (6-OHDA). At one day after maximally tolerated doses (400 mg/kg on two or five successive days) adrenergic nerve histofluorescence was abolished. Histofluorescence was again visible at eight days after treatment and was indistinguishable from controls at 30 days, a pattern also observed in heart and iris. In isolated tracheal segments from treated animals there was suppression of3H-norepinephrine uptake, supersensitivity to applied norepinephrine, and a decrease in the adrenergic component of electrical stimulation-induced relaxation. We conclude that 6-OHDA is effective in producing fairly complete, but transient, adrenergic denervation of guinea pig airways.",

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AB - We studied adrenergic nerve morphology and function in guinea pig trachea in relationship to dose and time after administration of 6-hydroxy dopamine (6-OHDA). At one day after maximally tolerated doses (400 mg/kg on two or five successive days) adrenergic nerve histofluorescence was abolished. Histofluorescence was again visible at eight days after treatment and was indistinguishable from controls at 30 days, a pattern also observed in heart and iris. In isolated tracheal segments from treated animals there was suppression of3H-norepinephrine uptake, supersensitivity to applied norepinephrine, and a decrease in the adrenergic component of electrical stimulation-induced relaxation. We conclude that 6-OHDA is effective in producing fairly complete, but transient, adrenergic denervation of guinea pig airways.

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Adrenergic denervation of guinea pig trachea with 6-hydroxydopamine

Abstract

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