Adrenalectomy increases reduced nicotinamide adenine dinucleotide phosphate-diaphorase activity in the rat spinal trigeminal subnucleus caudalis

Charles B. Hathaway; Thomas P. Collins; David A. Bereiter

doi:10.1016/0006-8993(95)01461-6

Adrenalectomy increases reduced nicotinamide adenine dinucleotide phosphate-diaphorase activity in the rat spinal trigeminal subnucleus caudalis

Charles B. Hathaway, Thomas P. Collins, David A. Bereiter

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4 Scopus citations

Abstract

Neurons exhibiting reduced nicotinamide adenine dinucleotide phosphate-diaphorase activity (NADPHd) were quantified at 500 μm rostrocaudal intervals in spinal trigeminal nucleus (Vsp) of adenalectomized (ADX), ADX + corticosterone, and sham-ADX rats 6-12 days after surgery. NADPHd neurons were found predominantly in Vsp subnucleus caudalis (Vc) and in dorsomedial subnucleus oralis. ADX significantly increased the number of NADPHd neurons in superficial laminae of Vc, an effect reversed by chronic corticosterone replacement. ADX effects on NADPHd in superficial laminae of Vc but not in deep laminae of Vc or in the periobex region of Vsp paralleled previously observed sites of ADX enhancement of noxious stimulus-induced Fos-like immunoreactivity. The results indicate that chronic changes in adrenal steroid status regulate NADPHd, a mechanism that may both derive from changes in nitric oxide synthase expression and influence the processing of nociceptive information by central trigeminal neurons.

Original language	English (US)
Pages (from-to)	143-147
Number of pages	5
Journal	Brain Research
Volume	712
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(95)01461-6
State	Published - Mar 11 1996

Bibliographical note

Funding Information:
The authorst hankD ominiqueF . Bereiterf or excellent technicaal ssistanceT.h is work was supportedin part by NIH grant NS 26137 (D.A.B.). C.B.H. was supportedin part by NIH trainingG rantGM 08206.

Keywords

Brainstem
Dorsal horn
Glucocorticoid
Nitric oxide
Nitric oxide synthase
Nociception

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10.1016/0006-8993(95)01461-6

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title = "Adrenalectomy increases reduced nicotinamide adenine dinucleotide phosphate-diaphorase activity in the rat spinal trigeminal subnucleus caudalis",

abstract = "Neurons exhibiting reduced nicotinamide adenine dinucleotide phosphate-diaphorase activity (NADPHd) were quantified at 500 μm rostrocaudal intervals in spinal trigeminal nucleus (Vsp) of adenalectomized (ADX), ADX + corticosterone, and sham-ADX rats 6-12 days after surgery. NADPHd neurons were found predominantly in Vsp subnucleus caudalis (Vc) and in dorsomedial subnucleus oralis. ADX significantly increased the number of NADPHd neurons in superficial laminae of Vc, an effect reversed by chronic corticosterone replacement. ADX effects on NADPHd in superficial laminae of Vc but not in deep laminae of Vc or in the periobex region of Vsp paralleled previously observed sites of ADX enhancement of noxious stimulus-induced Fos-like immunoreactivity. The results indicate that chronic changes in adrenal steroid status regulate NADPHd, a mechanism that may both derive from changes in nitric oxide synthase expression and influence the processing of nociceptive information by central trigeminal neurons.",

keywords = "Brainstem, Dorsal horn, Glucocorticoid, Nitric oxide, Nitric oxide synthase, Nociception",

author = "Hathaway, {Charles B.} and Collins, {Thomas P.} and Bereiter, {David A.}",

note = "Funding Information: The authorst hankD ominiqueF . Bereiterf or excellent technicaal ssistanceT.h is work was supportedin part by NIH grant NS 26137 (D.A.B.). C.B.H. was supportedin part by NIH trainingG rantGM 08206.",

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AU - Collins, Thomas P.

AU - Bereiter, David A.

N1 - Funding Information: The authorst hankD ominiqueF . Bereiterf or excellent technicaal ssistanceT.h is work was supportedin part by NIH grant NS 26137 (D.A.B.). C.B.H. was supportedin part by NIH trainingG rantGM 08206.

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N2 - Neurons exhibiting reduced nicotinamide adenine dinucleotide phosphate-diaphorase activity (NADPHd) were quantified at 500 μm rostrocaudal intervals in spinal trigeminal nucleus (Vsp) of adenalectomized (ADX), ADX + corticosterone, and sham-ADX rats 6-12 days after surgery. NADPHd neurons were found predominantly in Vsp subnucleus caudalis (Vc) and in dorsomedial subnucleus oralis. ADX significantly increased the number of NADPHd neurons in superficial laminae of Vc, an effect reversed by chronic corticosterone replacement. ADX effects on NADPHd in superficial laminae of Vc but not in deep laminae of Vc or in the periobex region of Vsp paralleled previously observed sites of ADX enhancement of noxious stimulus-induced Fos-like immunoreactivity. The results indicate that chronic changes in adrenal steroid status regulate NADPHd, a mechanism that may both derive from changes in nitric oxide synthase expression and influence the processing of nociceptive information by central trigeminal neurons.

AB - Neurons exhibiting reduced nicotinamide adenine dinucleotide phosphate-diaphorase activity (NADPHd) were quantified at 500 μm rostrocaudal intervals in spinal trigeminal nucleus (Vsp) of adenalectomized (ADX), ADX + corticosterone, and sham-ADX rats 6-12 days after surgery. NADPHd neurons were found predominantly in Vsp subnucleus caudalis (Vc) and in dorsomedial subnucleus oralis. ADX significantly increased the number of NADPHd neurons in superficial laminae of Vc, an effect reversed by chronic corticosterone replacement. ADX effects on NADPHd in superficial laminae of Vc but not in deep laminae of Vc or in the periobex region of Vsp paralleled previously observed sites of ADX enhancement of noxious stimulus-induced Fos-like immunoreactivity. The results indicate that chronic changes in adrenal steroid status regulate NADPHd, a mechanism that may both derive from changes in nitric oxide synthase expression and influence the processing of nociceptive information by central trigeminal neurons.

KW - Brainstem

KW - Dorsal horn

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KW - Nitric oxide synthase

KW - Nociception

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Adrenalectomy increases reduced nicotinamide adenine dinucleotide phosphate-diaphorase activity in the rat spinal trigeminal subnucleus caudalis

Abstract

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Keywords

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