Endogenous opioids have been shown to initiate feeding in sated animals. In the present study adrenalectomy enhanced the feeding response to the kappa opiate agonist, ethylketocyclazocine and the kappa/sigma opiate agonist, butorphanol tartrate. Adrenalectomy abolished the anorectic effect of naloxone at doses as high as 10 mg/kg. Corticosterone replacement did not alter the opiate induced feeding and adrenal demedullated rats continued to show enhancement to opiate induced feeding. These data suggest that in addition to the central nervous system. the adrenal medulla is involved in opiate related induction of feeding.
Bibliographical noteFunding Information:
We thank Martha Grace and Julie Kneip for their excellent technical assistance and JoAnn Tallman for her expert secretarial aid. Naloxone was graciously supplied by Endo Laboratories and butorphanol tartrate by Bristol I,aboratories. This work was supported by the Veterans Administration and General Mills, Inc.
Copyright 2014 Elsevier B.V., All rights reserved.
- Butorphanol tartrate
- Opiate-induced feeding