Adrenal Corticosteroids Cause Gastrin Cell Hyperplasia

John P. Delaney; Hector M. Michel; Margaret E. Bonsack; M. Michael Eisenberg; Daniel H. Dunn

doi:10.1016/S0016-5085(79)91317-9

Adrenal Corticosteroids Cause Gastrin Cell Hyperplasia

John P. Delaney
, Hector M. Michel
, Margaret E. Bonsack
, M. Michael Eisenberg
, Daniel H. Dunn

Surgery

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Chronic exogenous high dose adrenal cortical steroid administration to dogs resulted in a 137% increase in G-cell mass with an associated enhancement of peak serum gastrin levels. Adrenalectomy caused a halving of G-cell numbers without significant changes in serum gastrin levels. Adrenal cortical steroids appear to have an important trophic role for the G-cell.

Original language	English (US)
Pages (from-to)	913-916
Number of pages	4
Journal	Gastroenterology
Volume	76
Issue number	5
DOIs	https://doi.org/10.1016/S0016-5085(79)91317-9
State	Published - 1979

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title = "Adrenal Corticosteroids Cause Gastrin Cell Hyperplasia",

abstract = "Chronic exogenous high dose adrenal cortical steroid administration to dogs resulted in a 137\% increase in G-cell mass with an associated enhancement of peak serum gastrin levels. Adrenalectomy caused a halving of G-cell numbers without significant changes in serum gastrin levels. Adrenal cortical steroids appear to have an important trophic role for the G-cell.",

author = "Delaney, \{John P.\} and Michel, \{Hector M.\} and Bonsack, \{Margaret E.\} and Eisenberg, \{M. Michael\} and Dunn, \{Daniel H.\}",

year = "1979",

doi = "10.1016/S0016-5085(79)91317-9",

language = "English (US)",

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journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders",

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TY - JOUR

T1 - Adrenal Corticosteroids Cause Gastrin Cell Hyperplasia

AU - Delaney, John P.

AU - Michel, Hector M.

AU - Bonsack, Margaret E.

AU - Eisenberg, M. Michael

AU - Dunn, Daniel H.

PY - 1979

Y1 - 1979

N2 - Chronic exogenous high dose adrenal cortical steroid administration to dogs resulted in a 137% increase in G-cell mass with an associated enhancement of peak serum gastrin levels. Adrenalectomy caused a halving of G-cell numbers without significant changes in serum gastrin levels. Adrenal cortical steroids appear to have an important trophic role for the G-cell.

AB - Chronic exogenous high dose adrenal cortical steroid administration to dogs resulted in a 137% increase in G-cell mass with an associated enhancement of peak serum gastrin levels. Adrenalectomy caused a halving of G-cell numbers without significant changes in serum gastrin levels. Adrenal cortical steroids appear to have an important trophic role for the G-cell.

UR - https://www.scopus.com/pages/publications/0018421822

UR - https://www.scopus.com/pages/publications/0018421822#tab=citedBy

U2 - 10.1016/S0016-5085(79)91317-9

DO - 10.1016/S0016-5085(79)91317-9

M3 - Article

C2 - 437419

AN - SCOPUS:0018421822

SN - 0016-5085

VL - 76

SP - 913

EP - 916

JO - Gastroenterology

JF - Gastroenterology

IS - 5

ER -

Adrenal Corticosteroids Cause Gastrin Cell Hyperplasia

Abstract

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