Adrenal Corticosteroids Cause Gastrin Cell Hyperplasia

John P. Delaney, Hector M. Michel, Margaret E. Bonsack, M. Michael Eisenberg, Daniel H. Dunn

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Chronic exogenous high dose adrenal cortical steroid administration to dogs resulted in a 137% increase in G-cell mass with an associated enhancement of peak serum gastrin levels. Adrenalectomy caused a halving of G-cell numbers without significant changes in serum gastrin levels. Adrenal cortical steroids appear to have an important trophic role for the G-cell.

Original languageEnglish (US)
Pages (from-to)913-916
Number of pages4
Issue number5
StatePublished - 1979


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