Abstract
Necrotic lesions and cavities filled with caseum are a hallmark of mycobacterial pulmonary disease. Bronchocavitary Mycobacterium abscessus disease is associated with poor treatment outcomes. In caseum surrogate, M. abscessus entered an extended stationary phase showing tolerance to killing by most current antibiotics, suggesting that caseum persisters contribute to the poor performance of available treatments. Novel ADP-ribosylation-resistant rifabutin analogs exhibited bactericidal activity against these M. abscessus persisters at concentrations achievable by rifamycins in caseum.
Original language | English (US) |
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Journal | Antimicrobial agents and chemotherapy |
Volume | 67 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2023 |
Bibliographical note
Publisher Copyright:Copyright © 2023 Xie et al.
Keywords
- ADP-ribosylase
- NTM
- caseum
- drug tolerance
- non-tuberculous mycobacteria
- persistence
- rifamycins
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural