Administration of secretin (RG1068) increases the sensitivity of detection of duct abnormalities by magnetic resonance cholangiopancreatography in patients with pancreatitis

Stuart Sherman, Martin L. Freeman, Paul R. Tarnasky, C. Mel Wilcox, Abhijit Kulkarni, Alex M. Aisen, David Jacoby, Richard A. Kozarek

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Background & Aims Administration of secretin improves noninvasive imaging of the pancreatic duct with magnetic resonance cholangiopancreatography (MRCP). We performed a large prospective study to investigate whether synthetic human secretin (RG1068)-stimulated MRCP detects pancreatic duct abnormalities with higher levels of sensitivity than MRCP. Methods We performed a phase 3, multicenter, baseline-controlled study of patients with acute or acute recurrent pancreatitis who were scheduled to undergo endoscopic retrograde cholangiopancreatography (ERCP) between March 26, 2008, and October 28, 2009. Patients underwent a baseline MRCP that was immediately followed by administration of RG1068 and repeat MRCP and then underwent ERCP within 30 days; they were followed up for 30 days. MRCP and ERCP images were read centrally by 3 radiologists and 2 endoscopists, respectively, who were all independent and blinded; pancreatic duct abnormalities were evaluated. The accuracy of MRCP was evaluated using ERCP as the standard. Results In total, 258 patients were enrolled in the study; 251 MRCP image sets were assessed, and 236 patients had evaluable ERCPs. Pancreatic duct abnormalities were observed in 60.2% of ERCP images. All radiologists identified duct abnormalities in RG1068-ciné MRCP image sets with significantly higher levels of sensitivity (P <.0001) than in images from MRCP, with minimal loss of specificity. Adverse events were reported in 38.0% of patients after MRCP and 68.1% after ERCP. Of the 55 patients who experienced a serious adverse event, 3 (1.2%) and 52 (20.5%) of the events were reported to be temporally associated with MRCP and ERCP, respectively. The adverse events most frequently considered related to RG1068 were nausea, abdominal pain, and flushing; most were mild. Conclusions Compared with images from MRCP, those from RG1068-stimulated MRCP are improved in many aspects and could aid in diagnosis and clinical decision making for patients with acute, acute recurrent, or chronic pancreatitis. RG1068-enhanced MRCP might also better identify patients in need of therapeutic ERCP (, Number: NCT00660335).

Original languageEnglish (US)
Pages (from-to)646-654.e2
Issue number3
StatePublished - Sep 2014

Bibliographical note

Funding Information:
The authors thank their fellow principal investigators (listed in the Supplementary Appendix ) for their participation in this study as well as Fiona Boswell, PhD, and Jan Markind, PharmD, CMPP (Caudex Medical, New York, NY), for their assistance in the preparation of this manuscript, which was supported by Repligen Corp.


  • Direct Comparison
  • Increasing Resolution
  • Pancreas
  • Peptide Hormone


Dive into the research topics of 'Administration of secretin (RG1068) increases the sensitivity of detection of duct abnormalities by magnetic resonance cholangiopancreatography in patients with pancreatitis'. Together they form a unique fingerprint.

Cite this