Adjuvant activity for alkylamines of immune responses to ovalbumin, myelin basic protein and a tumor

W. Thomas Shier, Joseph T. Trotter, Christopher L. Reading, Vanda A. Lennon

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Emulsions of ovalbumin in alkylamines, particularly octadecylamine, were compared with an emulsion of ovalbumin in complete Freund’s adjuvant for ability to induce humoral and cell-mediated immune responses in rats. Under defined conditions alkylamine emulsions induced significantly higher IgG immune responses to ovalbumin, but cell-mediated immunity was not significantly different from that induced with complete Freund’s adjuvant. Emulsions of syngeneic myelin basic protein in octadecylamine failed to induce either humoral or cell-mediated immunity to basic protein and neither clinical nor histologic signs of experimental allergic encephalomyelitis ensued. An intranodular injection of octadecylamine into a solid tumor caused significantly enhanced growth of the tumor despite marked necrosis of tumor tissue at the site of injection.

Original languageEnglish (US)
Pages (from-to)688-695
Number of pages8
JournalInternational Archives of Allergy and Immunology
Volume47
Issue number5
DOIs
StatePublished - Jan 1 1974

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