TY - JOUR

T1 - Adjusting a relative-risk estimate for study imperfections

AU - Maldonado, G.

PY - 2008/7

Y1 - 2008/7

N2 - A statistical analysis combines data with assumptions to yield a quantitative result that is a function of both. One goal of an epidemiological analysis, then, should be to combine data with good assumptions. Unfortunately, a typical quantitative epidemiological analysis combines data with an assumption for which there is neither theoretical nor empirical justification. The assumption is that study imperfections (eg residual confounding, subject losses, non-random subject sampling, subject non-response, exclusions because of missing data, measurement error, incorrect statistical assumptions) have no important impact on study results. The author explains how a typical epidemiological analysis implicitly makes this assumption. It is then shown how in a quantitative analysis the assumption can be replaced with a better one. A simple, everyday example to illustrate the fundamental concepts is used to begin with. The relationship between an observed relative risk, the true causal relative risk and error terms that describe the impact of study imperfections on study results is described mathematically. This mathematical description can be used to quantitatively adjust a relative-risk estimate for the combined effect of study imperfections.

AB - A statistical analysis combines data with assumptions to yield a quantitative result that is a function of both. One goal of an epidemiological analysis, then, should be to combine data with good assumptions. Unfortunately, a typical quantitative epidemiological analysis combines data with an assumption for which there is neither theoretical nor empirical justification. The assumption is that study imperfections (eg residual confounding, subject losses, non-random subject sampling, subject non-response, exclusions because of missing data, measurement error, incorrect statistical assumptions) have no important impact on study results. The author explains how a typical epidemiological analysis implicitly makes this assumption. It is then shown how in a quantitative analysis the assumption can be replaced with a better one. A simple, everyday example to illustrate the fundamental concepts is used to begin with. The relationship between an observed relative risk, the true causal relative risk and error terms that describe the impact of study imperfections on study results is described mathematically. This mathematical description can be used to quantitatively adjust a relative-risk estimate for the combined effect of study imperfections.

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U2 - 10.1136/jech.2007.063909

DO - 10.1136/jech.2007.063909

M3 - Article

C2 - 18559450

AN - SCOPUS:46949084422

VL - 62

SP - 655

EP - 663

JO - Journal of Epidemiology and Community Health

JF - Journal of Epidemiology and Community Health

SN - 0143-005X

IS - 7

ER -