Adjunctive Measures for Treating Surgical Infections and Sepsis

Matthew C. Byrnes, Gregory J Beilman

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The history of adjunctive treatments for severe sepsis has been fraught with more failures than successes. To date, there have been few interventions that have been demonstrated to be efficacious by multiple large, well-designed, multicenter randomized clinical trials. However, recent research into treatment strategies using drotrecogin alfa (activated), effective blood glucose management, early goal-directed therapy, protocolization of care, and intensivist management has demonstrated positive results. Further research is being conducted to verify the success of these initial trials. This article summarizes some of the available adjunctive treatments for severe sepsis.

Original languageEnglish (US)
Pages (from-to)349-363
Number of pages15
JournalSurgical Clinics of North America
Volume89
Issue number2
DOIs
StatePublished - Apr 1 2009

Fingerprint

Sepsis
Infection
Research
Blood Glucose
Randomized Controlled Trials
History
Therapeutics
drotrecogin alfa activated

Keywords

  • Activated protein C
  • Adjunctive therapy
  • Glycemic control
  • Sepsis bundles
  • Vasopressors

Cite this

Adjunctive Measures for Treating Surgical Infections and Sepsis. / Byrnes, Matthew C.; Beilman, Gregory J.

In: Surgical Clinics of North America, Vol. 89, No. 2, 01.04.2009, p. 349-363.

Research output: Contribution to journalReview article

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