Adipose tissue metabolism and genetic obesity: The LPL hypothesis

M. R.C. Greenwood, M. Cleary, L. Steingrimsdottir, J. R. Vasselli

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The cellular mechanism(s) which lead to the development of genetic obesity are presently unknown. However, the earliest postnatal alterations lead to disturbed body composition even during the preobese suckling stage. The demonstration that adipose tissue lipoprotein lipase is elevated in the first to second week of age in the absence of hyperphagia and prior to other putative agonists has lead to a hypothesis predicting the subsequent onset of the hypercellular-hypertrophic obese state. Data to support this 'LPL hypothesis' are described.

Original languageEnglish (US)
Number of pages1
JournalInternational Journal of Obesity
Issue number6
StatePublished - Jan 1 1981

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    Greenwood, M. R. C., Cleary, M., Steingrimsdottir, L., & Vasselli, J. R. (1981). Adipose tissue metabolism and genetic obesity: The LPL hypothesis. International Journal of Obesity, 5(6).