TY - JOUR
T1 - Adipokines
T2 - A reviewof biological and analytical principles and an update in dogs, cats, and horses
AU - Radin, M. Judith
AU - Sharkey, Leslie C.
AU - Holycross, Bethany J.
PY - 2009/6
Y1 - 2009/6
N2 - In addition to its role as an energy storage depot, adipose tissue is now recognized as a complex endocrine organ. Adipose tissue releases a variety of factors, termed adipokines, that regulate energy metabolism, cardiovascular function, reproductive status, and immune function. Some of the better-studied adipokines include leptin, adiponectin, and components of the renin-angiotensin system such as angiotensinogen. The function of more recently discovered adipokines such as resistin are under intense scrutiny. Abnormal production or regulation of adipokines occurs in obese individuals and is implicated in the development of a variety of associated co-morbidities including metabolic syndrome, type 2 diabetes, atherosclerosis, heart disease, and cancer in people, although evaluation in domestic species is just beginning. Adipokines are now being examined as potential biomarkers for risk assessment for development of complications related to obesity. This article summarizes the function and regulation of some better-characterized adipokines. It also reviews the current information on the characterization of adipokines in some domestic species in which rates of obesity and obesityrelated disorders are increasing, such as the dog, cat, and horse.
AB - In addition to its role as an energy storage depot, adipose tissue is now recognized as a complex endocrine organ. Adipose tissue releases a variety of factors, termed adipokines, that regulate energy metabolism, cardiovascular function, reproductive status, and immune function. Some of the better-studied adipokines include leptin, adiponectin, and components of the renin-angiotensin system such as angiotensinogen. The function of more recently discovered adipokines such as resistin are under intense scrutiny. Abnormal production or regulation of adipokines occurs in obese individuals and is implicated in the development of a variety of associated co-morbidities including metabolic syndrome, type 2 diabetes, atherosclerosis, heart disease, and cancer in people, although evaluation in domestic species is just beginning. Adipokines are now being examined as potential biomarkers for risk assessment for development of complications related to obesity. This article summarizes the function and regulation of some better-characterized adipokines. It also reviews the current information on the characterization of adipokines in some domestic species in which rates of obesity and obesityrelated disorders are increasing, such as the dog, cat, and horse.
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U2 - 10.1111/j.1939-165X.2009.00133.x
DO - 10.1111/j.1939-165X.2009.00133.x
M3 - Article
C2 - 19392760
AN - SCOPUS:69449092412
SN - 0275-6382
VL - 38
SP - 136
EP - 156
JO - Veterinary Clinical Pathology
JF - Veterinary Clinical Pathology
IS - 2
ER -