Adhesions ring: A structural comparison between podosomes and the immune synapse

Sarah A. Wernimont; Christa L. Cortesio; William T.N. Simonson; Anna Huttenlocher

doi:10.1016/j.ejcb.2008.01.011

Adhesions ring: A structural comparison between podosomes and the immune synapse

Sarah A. Wernimont, Christa L. Cortesio, William T.N. Simonson, Anna Huttenlocher

Research output: Contribution to journal › Short survey › peer-review

15 Scopus citations

Abstract

Podosomes and the immune synapse are integrin-mediated adhesive structures that share a common ring-like morphology. Both podosomes and immune synapses have a central core surrounded by a peripheral ring containing talin, vinculin and paxillin. Recent progress suggests significant parallels between the regulatory mechanisms that contribute to the formation of these adhesive structures. In this review, we compare the structures, functions and regulation of podosomes and the immune synapse.

Original language	English (US)
Pages (from-to)	507-515
Number of pages	9
Journal	European Journal of Cell Biology
Volume	87
Issue number	8-9
DOIs	https://doi.org/10.1016/j.ejcb.2008.01.011
State	Published - Sep 4 2008
Externally published	Yes

Keywords

Immune synapse
Invadopodia
Podosome

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10.1016/j.ejcb.2008.01.011

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abstract = "Podosomes and the immune synapse are integrin-mediated adhesive structures that share a common ring-like morphology. Both podosomes and immune synapses have a central core surrounded by a peripheral ring containing talin, vinculin and paxillin. Recent progress suggests significant parallels between the regulatory mechanisms that contribute to the formation of these adhesive structures. In this review, we compare the structures, functions and regulation of podosomes and the immune synapse.",

keywords = "Immune synapse, Invadopodia, Podosome",

author = "Wernimont, {Sarah A.} and Cortesio, {Christa L.} and Simonson, {William T.N.} and Anna Huttenlocher",

year = "2008",

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doi = "10.1016/j.ejcb.2008.01.011",

language = "English (US)",

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T2 - A structural comparison between podosomes and the immune synapse

AU - Wernimont, Sarah A.

AU - Cortesio, Christa L.

AU - Simonson, William T.N.

AU - Huttenlocher, Anna

PY - 2008/9/4

Y1 - 2008/9/4

N2 - Podosomes and the immune synapse are integrin-mediated adhesive structures that share a common ring-like morphology. Both podosomes and immune synapses have a central core surrounded by a peripheral ring containing talin, vinculin and paxillin. Recent progress suggests significant parallels between the regulatory mechanisms that contribute to the formation of these adhesive structures. In this review, we compare the structures, functions and regulation of podosomes and the immune synapse.

AB - Podosomes and the immune synapse are integrin-mediated adhesive structures that share a common ring-like morphology. Both podosomes and immune synapses have a central core surrounded by a peripheral ring containing talin, vinculin and paxillin. Recent progress suggests significant parallels between the regulatory mechanisms that contribute to the formation of these adhesive structures. In this review, we compare the structures, functions and regulation of podosomes and the immune synapse.

KW - Immune synapse

KW - Invadopodia

KW - Podosome

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UR - http://www.scopus.com/inward/citedby.url?scp=49049116497&partnerID=8YFLogxK

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SN - 0171-9335

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EP - 515

JO - European Journal of Cell Biology

JF - European Journal of Cell Biology

IS - 8-9

ER -

Adhesions ring: A structural comparison between podosomes and the immune synapse

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Keywords

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