Adhesions ring: A structural comparison between podosomes and the immune synapse

Sarah A. Wernimont, Christa L. Cortesio, William T.N. Simonson, Anna Huttenlocher

Research output: Contribution to journalShort surveypeer-review

14 Scopus citations

Abstract

Podosomes and the immune synapse are integrin-mediated adhesive structures that share a common ring-like morphology. Both podosomes and immune synapses have a central core surrounded by a peripheral ring containing talin, vinculin and paxillin. Recent progress suggests significant parallels between the regulatory mechanisms that contribute to the formation of these adhesive structures. In this review, we compare the structures, functions and regulation of podosomes and the immune synapse.

Original languageEnglish (US)
Pages (from-to)507-515
Number of pages9
JournalEuropean Journal of Cell Biology
Volume87
Issue number8-9
DOIs
StatePublished - Sep 4 2008
Externally publishedYes

Keywords

  • Immune synapse
  • Invadopodia
  • Podosome

Fingerprint Dive into the research topics of 'Adhesions ring: A structural comparison between podosomes and the immune synapse'. Together they form a unique fingerprint.

Cite this