Adhesion of sickle red cells to endothelium: Myths and future directions

R. P. Hebbel

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Sickle RBC are abnormally adherent to vascular endothelial cells. We briefly review the mechanisms that underlie this type of cell/cell adhesion, expose a number of extant myths about RBC adhesion, and discuss some aspects that need consideration via future experimentation. The relationship of this phenomenon of RBC-endothelial adhesion to the cytoadherence of parasitized sickle RBC is not yet clear.

Original languageEnglish (US)
Pages (from-to)14-18
Number of pages5
JournalTransfusion Clinique et Biologique
Volume15
Issue number1-2
DOIs
StatePublished - Feb 2008

Keywords

  • Adhesion
  • Antiadhesogen
  • Endothelium

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