Adherence to Enhanced Recovery Protocols in NSQIP and Association with Colectomy Outcomes

Julia R. Berian, Kristen A. Ban, Jason B. Liu, Clifford Y. Ko, Liane S. Feldman, Julie K. Thacker

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To evaluate the effect of protocol adherence on length of stay (LOS) and recovery-specific outcomes after colectomy. Background: Enhanced recovery protocols (ERPs) may decrease postoperative morbidity and LOS; however, the effect of overall protocol adherence remains unclear. Methods: Using American College of Surgeons' National Surgical Quality Improvement Program colectomy data (July 2014-December 2015) and 13 novel ERP variables, propensity scores were constructed for low (0-5), moderate (6-9), and high adherence (10-13 components). Prolonged LOS (>75th percentile, uncomplicated cases) was modeled with multivariable logistic regression with robust standard errors, adjusted for hospital-level clustering and propensity score. Secondary recovery-specific outcomes were modeled with negative binomial regression. Subgroup analysis was conducted on uncomplicated cases. Results: Among 8139 elective colectomies at 113 hospitals, LOS increased with decreasing adherence (4.3 days [SD 3.3] high adherence vs 7.8 [SD 6.8] low adherence; P < 0.0001). High adherence was associated with fewer complications, including postoperative ileus, compared with moderate (P < 0.0001) and low adherence (P < 0.0001). High-adherence patients achieved recovery milestones earlier (vs low adherence), with return of bowel function at 1.9 (vs 3.7) days, tolerance of diet at 2.4 (vs 5.4) days, and oral pain control at 2.7 (vs 5.0) days (P < 0.0001). Risk-adjusted odds of prolonged LOS were significantly increased for low (odds ratio 2.7, 95% confidence interval 2.0-3.6) and moderate-adherence (odds ratio 1.7, 95% confidence interval 1.4-2.1) groups. In a negative binomial regression, time to recovery was 60% to 95% longer for low versus high adherence (P < 0.0001). Conclusions: In this large, multi-institutional North American data registry, high adherence to ERPs was associated with earlier recovery, decreased complications, and shorter LOS. ERPs can improve outcomes; however, benefits correlate with adherence.

Original languageEnglish (US)
Pages (from-to)486-493
Number of pages8
JournalAnnals of surgery
Volume269
Issue number3
DOIs
StatePublished - Mar 1 2019

Fingerprint

Colectomy
Length of Stay
Propensity Score
Odds Ratio
Confidence Intervals
Ileus
Patient Compliance
Quality Improvement
Cluster Analysis
Registries
Logistic Models
Diet
Morbidity
Pain

Keywords

  • colectomy outcomes
  • enhanced recovery
  • implementation science
  • protocol adherence
  • protocol compliance
  • quality improvement

PubMed: MeSH publication types

  • Journal Article
  • Observational Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

Cite this

Adherence to Enhanced Recovery Protocols in NSQIP and Association with Colectomy Outcomes. / Berian, Julia R.; Ban, Kristen A.; Liu, Jason B.; Ko, Clifford Y.; Feldman, Liane S.; Thacker, Julie K.

In: Annals of surgery, Vol. 269, No. 3, 01.03.2019, p. 486-493.

Research output: Contribution to journalArticle

Berian, Julia R. ; Ban, Kristen A. ; Liu, Jason B. ; Ko, Clifford Y. ; Feldman, Liane S. ; Thacker, Julie K. / Adherence to Enhanced Recovery Protocols in NSQIP and Association with Colectomy Outcomes. In: Annals of surgery. 2019 ; Vol. 269, No. 3. pp. 486-493.
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AU - Feldman, Liane S.

AU - Thacker, Julie K.

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N2 - Objective: To evaluate the effect of protocol adherence on length of stay (LOS) and recovery-specific outcomes after colectomy. Background: Enhanced recovery protocols (ERPs) may decrease postoperative morbidity and LOS; however, the effect of overall protocol adherence remains unclear. Methods: Using American College of Surgeons' National Surgical Quality Improvement Program colectomy data (July 2014-December 2015) and 13 novel ERP variables, propensity scores were constructed for low (0-5), moderate (6-9), and high adherence (10-13 components). Prolonged LOS (>75th percentile, uncomplicated cases) was modeled with multivariable logistic regression with robust standard errors, adjusted for hospital-level clustering and propensity score. Secondary recovery-specific outcomes were modeled with negative binomial regression. Subgroup analysis was conducted on uncomplicated cases. Results: Among 8139 elective colectomies at 113 hospitals, LOS increased with decreasing adherence (4.3 days [SD 3.3] high adherence vs 7.8 [SD 6.8] low adherence; P < 0.0001). High adherence was associated with fewer complications, including postoperative ileus, compared with moderate (P < 0.0001) and low adherence (P < 0.0001). High-adherence patients achieved recovery milestones earlier (vs low adherence), with return of bowel function at 1.9 (vs 3.7) days, tolerance of diet at 2.4 (vs 5.4) days, and oral pain control at 2.7 (vs 5.0) days (P < 0.0001). Risk-adjusted odds of prolonged LOS were significantly increased for low (odds ratio 2.7, 95% confidence interval 2.0-3.6) and moderate-adherence (odds ratio 1.7, 95% confidence interval 1.4-2.1) groups. In a negative binomial regression, time to recovery was 60% to 95% longer for low versus high adherence (P < 0.0001). Conclusions: In this large, multi-institutional North American data registry, high adherence to ERPs was associated with earlier recovery, decreased complications, and shorter LOS. ERPs can improve outcomes; however, benefits correlate with adherence.

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