Adherence of Streptococcus pyogenes M type 5 to pharyngeal and buccal cells of patients with rheumatic fever and rheumatic heart disease during a one‐year follow‐up

K. S.NANDA KUMAR, NIRMAL K. GANGULY, INDER S. ANAND, PURSHOTAM L. WAHI

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Abstract

In vitro adherence of Streptococcus pyogenes M type 5 to isolated pharyngeal and buccal epithelial cells was studied in patients with acute recurrent rheumatic fever (n = 21), chronic rheumatic heart disease (n = 33), streptococcal pharyngitis (n = 12), and in normal controls. Patients were investigated at admission and one, six and 12 months later. Streptococci adhered significantly more to the pharyngeal cells of patients with rheumatic fever and rheumatic heart disease than to the pharyngeal cells of controls. Adherence of streptococci to pharyngeal cells of patients with pharyngitis was not different from age‐matched controls. The adherence of streptococci to the pharyngeal cells of patients with acute rheumatic fever fell during follow‐up but even after one year remained significantly higher than in the control group. These findings suggest that host factor(s) controlling streptococcal adhesion and colonization at the pharyngeal mucosa may be important in the pathogenesis of acute rheumatic fever.

Original languageEnglish (US)
Pages (from-to)353-359
Number of pages7
JournalAPMIS
Volume100
Issue number1-6
DOIs
StatePublished - Jan 1992

Keywords

  • Buccal cells
  • Streptococcal pharyngitis
  • Streptococcus pyogenes
  • pharyngeal cells
  • rheumatic fever
  • rheumatic heart disease

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