Adequacy, benefits, complications, dose and efficacy of filtration - the minneapolis experience

Prakash Keshaviah, Allan Collins, Robert Berkseth, Karen Ilstrup, James Ebben, Dave Hirsch, Doug Luehmann, Fred L. Shapiro

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4 Scopus citations


Twenty-four patients were studied in an A-B-A format with 3 months of control hemodialysis, 12 months of hemofiltration, and 3 months return to control hemodialysis. Hemofiltration was performed in the postdilution mode using substitution fluid produced on-site, therapy being individually prescribed to match the creatinine removal on control hemodialysis. Stable serum chemistries and hematology were noted with hemofiltration, there being an improvement in the acid-base status of the patients. Less posttreatment fatigue, better blood pressure control, a lower incidence of hypotension, fever and cramps, and a reduced frequency and volume of fluid administration were achieved with hemofiltration. The incidence of nausea, vomiting, headaches, and pruritus was, however, higher with hemofiltration. A low incidence of pyrogen reactions (0.2%) with low associated morbidity was noted, demonstrating the safety of on-site production of substitution fluid for hemofiltration. Some of the improvements noted with hemofiltration persisted during the second control period of hemodialysis for reasons that are not clear.

Original languageEnglish (US)
Pages (from-to)149-157
Number of pages9
JournalBlood Purification
Issue number3
StatePublished - 1984


  • Adequacy
  • Complications
  • Efficacy
  • Hemodialysis
  • Hemofiltration
  • On-site production
  • Substitution fluid


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