Adenovirus composition, proteolysis, and disassembly studied by in-depth qualitative and quantitative proteomics

Marco Benevento, Serena Di Palma, Joost Snijder, Crystal L. Moyer, Vijay S. Reddy, Glen R. Nemerow, Albert J.R. Heck

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Background: Adenoviruses (AdV) are broadly employed as gene delivery vectors. Results: Copy numbers of all AdV proteins were measured, and the release of proteins upon heat stress investigated. Conclusion: The viral protease plays a distinct role in the segmented release of AdV proteins. Significance: Our characterization by mass spectrometry provides new insight in HAdV disassembly during entry into host cells.

Original languageEnglish (US)
Pages (from-to)11421-11430
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number16
DOIs
StatePublished - Apr 18 2014
Externally publishedYes

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